Sr Staff Program Manager
Twist Bioscience • South San Francisco, CA14d • $233,000 - $271,000 • Hybrid
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Sr Staff Program Manager, MES Custom Software Development Transformation
Twist Bioscience•South San Francisco, CA
•$233,000 - $271,000•Hybrid
About The Position
Twist Bioscience is undertaking a strategic transformation of its Manufacturing Execution System (MES) to modernize its technology platform, enable operational scalability, and support evolving business needs. The Sr Staff Program Manager will lead strategic planning, cross-functional coordination, and hands-on execution of this business-critical initiative, bringing structure, Agile delivery discipline, and program governance to the MES replatform effort. The role partners with Technology, Manufacturing Operations, R&D, Quality, and business stakeholders to align priorities, manage dependencies, and drive decisions. It reports directly to the Sr Director of Technology Operations. The position is hybrid in South San Francisco, California, or Wilsonville, Oregon. The California-based base cash compensation range is $233,000–$271,000 USD. The role is also eligible for a bonus, equity, and a benefits package; compensation may vary by location and candidate qualifications.
Requirements
- Bachelor’s degree in Computer Science, Software Engineering, Industrial Engineering, Information Technology, or a related field.
- At least 12 years of experience performing and improving business processes, with a strong focus on manufacturing, life sciences, engineering, or operations.
- Proven expertise in Agile project delivery frameworks, such as Scrum Master, SAFe, or PMI-ACP, and a strong track record facilitating Agile ceremonies and managing iteration cycles.
- At least 5 years of project or program management experience leading cross-functional custom software development teams.
- Hands-on understanding of the custom software development lifecycle (SDLC), modern software architecture principles, and business transformation frameworks.
- Strong leadership, negotiation, and conflict-resolution skills.
- Track record of translating complex manufacturing requirements into actionable software solutions.
Nice To Haves
- Biotech or pharmaceutical industry experience.
- Certified ScrumMaster (CSM), PMI-ACP, or SAFe Agilist certification.
- Specialized experience in biotech, pharmaceutical, semiconductor, or advanced discrete manufacturing environments.
- Deep understanding of custom software development lifecycles (SDLC), shop-floor manufacturing processes, SCADA/PLC integration, and ISA-95 standards.
Responsibilities
- Lead the overall MES replatform transformation and translate strategic objectives into an actionable, integrated program roadmap.
- Manage day-to-day MES replatform execution, including timelines, scope, resources, and deliverable milestones.
- Partner with business users, IT process owners, and external software vendors or agencies to communicate status, align expectations, and resolve cross-functional issues.
- Track project expenditures, support financial budgeting, and ensure efficient resource allocation across initiative tracks.
- Implement company and departmental procedures that affect immediate operations.
- Assist with organizational change management to support system adoption and transition from legacy platforms.
- Identify technical, operational, and integration risks proactively.
- Enforce quality-control practices, compliance standards, and validation protocols required in manufacturing software environments.
Benefits
- Bonus eligibility
- Equity
- Benefits package
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What This Job Offers
Job Type
Full-time
Career Level
Senior
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