Biochemistry Scientist Jobs

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Senior Scientist, Biochemistry

Pacific Biosciences•Menlo Park, CA
•Onsite

About The Position

PacBio is seeking a Senior Scientist to join an interdisciplinary team addressing biochemical challenges and advancing DNA sequencing technology. The successful candidate will contribute through hands-on laboratory experimentation, biochemical assay development, experimental design, and data analysis. The role suits a curious, creative, and motivated scientist who enjoys tackling challenging scientific problems, designing informative experiments, and collaborating with colleagues to develop innovative solutions. Non-field-based employees are required to work onsite Monday through Thursday, with Friday work from home. Depending on the role, some employees may be required to work 100% onsite. The employee may occasionally be required to visit and work at PacBio locations as the Company considers necessary for proper performance of duties. All listed tasks and responsibilities are essential functions, though business conditions may require reasonable accommodations for additional tasks and responsibilities.

Requirements

  • PhD in Biochemistry, Biophysics, Molecular Biology, Chemistry, or a related field.
  • A minimum of 2–5 years of related experience; postdoctoral experience may count.
  • Strong hands-on experience in biochemical or biophysical experimentation, including assay development, optimization, and troubleshooting.
  • Scientific curiosity, creativity, and analytical problem-solving skills.
  • Ability to effectively use AI-assisted tools for scientific research, experimental design, and data analysis.
  • Ability to work independently while contributing effectively to a collaborative team.
  • Excellent interpersonal, written, and verbal communication skills.
  • Current authorization to work in the United States without the need for present or future sponsorship.

Nice To Haves

  • Hands-on experience with single-molecule fluorescence microscopy or other single-molecule biophysical techniques.
  • Background in DNA polymerases, enzyme kinetics, DNA–protein interactions, or DNA sequencing technologies.
  • Experience in molecular biology techniques, including primer design, DNA manipulation, and use of custom-designed DNA substrates.
  • Knowledge of statistical methods and quantitative analysis of biochemical or biophysical data.

Responsibilities

  • Design and execute hypothesis-driven experiments that generate actionable insights to support sequencing chemistry development.
  • Develop, optimize, and troubleshoot biochemical and biophysical assays, including single-molecule approaches, to characterize reaction performance and evaluate potential solutions.
  • Design, source, and use custom DNA substrates and other specialized reagents for biochemical and biophysical experiments.
  • Analyze and interpret experimental data, assess reproducibility, and present findings and conclusions in scientific and project meetings.
  • Collaborate with scientists across disciplines to investigate technical challenges and develop solutions guided by biochemical insights.
  • Maintain accurate experimental records and contribute to experimental planning and scientific discussions.

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What This Job Offers

Job Type

Full-time

Career Level

Senior

Education Level

Ph.D. or professional degree

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Based on current job postings on Teal, the average Biochemistry Scientist salary in the US is approximately $61,000 per year, with a typical range of $50,000 to $71,000.
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