Research Scientist II, Biochemistry
About The Position
This laboratory-based in vitro Research Scientist position is part of Novartis Biomedical Research’s Cardiovascular and Metabolic Disease (CVM) research team in Cambridge, Massachusetts. The scientist will advance understanding of disease biology and contribute to the discovery of medicines for people with cardiovascular and metabolic diseases. Work in the CVM Biochemistry unit includes target validation, assay development, and drug profiling across exploratory and pipeline projects, using therapeutic molecules such as small molecules and biologics. The role collaborates with colleagues across the broader research organization.
Requirements
- Bachelor's or Master's degree in biology, biochemistry, cell biology, or a related life science field; at least a Bachelor's degree is required.
- At least 4 years of relevant post-graduate research experience.
- Strong attention to detail and the ability to quickly learn new techniques.
- Knowledge of statistics and computational data analysis.
- Strong communication and creative problem-solving skills, with the ability to work collaboratively in a matrixed team environment.
- Exemplary laboratory practices and record-keeping skills.
- Flexibility, an aptitude for learning, and a passion for driving groundbreaking science.
Nice To Haves
- Experience culturing, differentiating, and genetically engineering human induced pluripotent stem cell-derived cardiomyocytes via viral transduction.
- Research experience in cardiovascular or metabolic disease, such as heart failure, obesity, atrial fibrillation, or atherosclerosis.
Responsibilities
- Plan and execute biochemical and cell-based assays to support drug discovery.
- Perform in vitro experiments for assay development, therapeutic-lead profiling, target validation, and mechanism-of-action studies.
- Use core laboratory techniques, including cell culture, quantitative polymerase chain reaction, gene knockdown with small interfering RNA, immunofluorescence microscopy, and Western blotting.
- Analyze data and accurately document experiments in the electronic laboratory notebook.
- Present results at laboratory and department meetings.
- Assist in writing research documents and scientific publications.
Benefits
- Performance-based cash incentive.
- Depending on role level, eligibility to be considered for annual equity awards.
- Health benefits.
- Life benefits.
- Disability benefits.
- 401(k) with company contribution and match.
- Vacation, personal days, holidays, and other leave.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
