Scientist I, Biochemistry & Lead Discovery

Flagship Pioneering, Inc.•Cambridge, MA

1d•$100,000 - $126,500•Onsite

About The Position

Flagship Labs 111 Inc. (FL111), an early-stage biotechnology company developing therapeutic modalities through chemistry, computation, and data science, seeks an independent and motivated laboratory scientist for its Biochemistry team. The role focuses on biochemical and biophysical assay design, assay development, target engagement studies, and binding characterization for small molecules, heterobifunctionals, and related modalities. The scientist will work closely with chemistry and biology teams to inform hit-to-lead optimization and mechanism-of-action investigations. The position also contributes to team leadership, cross-functional collaboration, and scientific discussions supporting organizational growth. The role is based in Cambridge, Massachusetts. FL111 is backed by Flagship Pioneering. The company seeks collaborative, creative, and solutions-oriented problem solvers who are motivated by scientific and patient impact.

Requirements

MS or PhD in Biochemistry, Chemical Biology, Enzymology, or a related field.
For candidates with an MS: at least 8 years of relevant academic or industry experience.
For candidates with a PhD: 0–2 years of relevant academic or industry experience.
Deep understanding of protein chemistry and biophysics.
Hands-on experience working with small-molecule compounds.
Demonstrated ability to develop and troubleshoot biochemical assays independently.
Excellent communication skills and ability to work cross-functionally.
High degree of scientific independence, motivation, and solutions-oriented thinking.
Comfort operating in a fast-paced environment with shifting priorities.

Nice To Haves

Experience working with contract research organizations (CROs).

Responsibilities

Lead and execute biochemical assay development to monitor protein/ligand and protein/protein interactions.
Apply readout technologies such as FP, FRET, NanoBRET, or NanoBiT across active programs.
Drive protein purification and quality-control processes to support discovery efforts.
Set up and run high-throughput assays and troubleshoot independently to keep programs moving.
Partner with contract research organizations as needed to extend internal capacity.
Collaborate cross-functionally and contribute scientific input across multiple concurrent projects.
Contribute to team leadership and broader scientific discussions supporting organizational growth.
Conduct target engagement studies and binding characterization to inform hit-to-lead optimization and mechanism-of-action questions.