Scientist, Product Biochemistry

Regeneron Pharmaceuticals • Tarrytown, GA

1d • $93,900 - $153,300 • Onsite

About The Position

Regeneron is seeking an experienced and highly motivated Scientist to join the Product Biochemistry team. The role supports preparation and characterization of critical protein and biomolecule reagents used in preclinical and regulated assay development. The Scientist generates well-characterized, fit-for-purpose reagents, performs stability and characterization studies, and collaborates with cross-functional teams to meet project and assay-development timelines. This is a full-time, on-site position in Tarrytown, New York.

Requirements

• BS in Biochemistry, Biophysics, Engineering, or a related field with 8 or more years of relevant industry experience, or MS in one of these fields with 6 or more years of relevant industry experience.
• Strong hands-on experience in protein characterization, purification, and conjugation.
• Demonstrated experience with multiple protein analytical techniques, such as SDS-PAGE, Western blot, CE-SDS, SEC, UV-Vis spectroscopy, and IEF/cIEF.
• Experience with protein purification techniques, including affinity chromatography, ion exchange chromatography, size-exclusion chromatography, and FPLC systems.
• Strong understanding of protein biochemistry, including protein stability, aggregation, binding interactions, and the potential effects of chemical modification on protein properties.
• Strong laboratory documentation, data organization, and record-keeping skills.
• Ability to organize and prioritize multiple projects and deliverables in a fast-paced research environment.
• Strong problem-solving skills and ability to work independently with appropriate guidance.
• Ability to collaborate effectively across scientific and functional groups.
• Excellent verbal and written communication skills.

Nice To Haves

• Experience with protein labeling or conjugation, including biotin, fluorescent dyes, ruthenium, or related protein modifications.
• Experience with SPR/BLI-based binding characterization.
• Experience with additional biophysical or analytical methods such as LC-MS, MALDI-TOF MS, SEC-MALS, DLS, or DSC.
• Experience with Empower, UNICORN, or similar chromatography or data-analysis software.
• Experience supporting critical reagents used in bioanalytical, potency, or other regulated assays.
• Familiarity with GxP/GLP laboratory practices, controlled documentation, and reagent lifecycle or stability activities.

Responsibilities

• Perform comprehensive reagent characterization to evaluate identity, purity, stability, aggregation, binding properties, labeling efficiency, and fitness for intended use.
• Support preparation, purification, and conjugation of critical protein and biomolecule reagents for assay development and testing.
• Conduct routine and advanced protein analytical testing using techniques such as SDS-PAGE, Western blot, CE-SDS, SEC, UV-Vis spectroscopy, ELISA, and other protein characterization methods.
• Support stability characterization of critical reagents, including stability and freeze/thaw studies, and investigate factors affecting reagent stability and assay performance.
• Contribute to development and implementation of new analytical approaches and improved characterization strategies for critical reagents.
• Troubleshoot reagent quality, analytical methods, and instrumentation, and contribute to scientific problem-solving.
• Document experimental procedures, analytical results, and conclusions in the electronic laboratory notebook according to established procedures and timelines.
• Summarize experimental results in technical reports and presentations, and communicate findings at group and project meetings.
• Maintain and support laboratory instrumentation used for protein purification and characterization.
• Collaborate with cross-functional teams to coordinate reagent needs, priorities, and deliverables and support project timelines.
• Manage multiple reagent requests and characterization activities simultaneously while maintaining scientific quality and documentation standards.

Benefits

• Competitive and comprehensive total rewards package, which may include annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits, paid time off, and family support benefits.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior