Senior Scientist Jobs

About The Position

Requirements

• Ph.D. in Organic Chemistry or a related discipline with 5+ years of relevant industry experience, or an M.S. with 15+ years of relevant industry experience, including significant automated or parallel synthesis experience.
• Extensive hands-on experience in multi-step organic synthesis, reaction screening, and library synthesis.
• Demonstrated expertise programming and operating Chemspeed AutoSuite for automated synthesis and parallel chemistry workflows.
• Strong understanding of synthetic route design, reaction mechanisms, reaction optimization, and troubleshooting, particularly for parallel and microscale synthesis.
• Broad expertise in modern synthetic methodologies, including cross-coupling chemistry, amide bond formation, photo-redox catalysis, and C–H functionalization.
• Experience designing and executing high-throughput reaction screens and translating optimized conditions into preparative synthesis.
• Experience with automated and semi-automated purification platforms, such as Biotage, Teledyne ISCO, preparative HPLC, and SFC.
• Experience interpreting LC-MS, UPLC/HPLC, and other plate-based analytical data to assess reaction performance and compound quality.
• Strong understanding of automated liquid and solid handling, reaction miniaturization, and experimental reproducibility.
• Strong problem-solving skills and ability to diagnose complex synthetic, mechanical, and automation-related issues.
• Ability to work effectively in a collaborative, multidisciplinary drug discovery environment.
• Strong communication skills and ability to translate scientific requirements into practical automated workflows.
• Ability to manage multiple parallel chemistry campaigns and prioritize activities across discovery programs.

Nice To Haves

• Familiarity with additional laboratory automation platforms, such as Tecan EVO or related liquid-handling systems.
• Experience integrating automation workflows with ELN, LIMS, cheminformatics, or laboratory data systems.
• A continuous-improvement mindset and interest in applying automation, digital technologies, and data-driven approaches to accelerate medicinal chemistry.

Responsibilities

• Collaborate with medicinal chemistry project leaders, computational chemists, and AI scientists to identify, prioritize, and design chemical libraries that address project hypotheses and expand structure–activity relationships.
• Program, configure, operate, and maintain automated synthesis workstations, including Chemspeed FLEX/ISYNTH and SWILE platforms using AutoSuite.
• Design and execute parallel synthesis campaigns ranging from multi-gram intermediates to milligram final compounds.
• Develop and optimize microscale high-throughput experimentation workflows for reaction screening, catalyst and reagent evaluation, and reaction-condition optimization.
• Translate conventional synthetic procedures into robust, reproducible, scalable automated workflows for parallel execution.
• Calibrate, maintain, and troubleshoot automated hardware, including gravimetric powder-dosing systems, liquid-handling modules, viscous-liquid dispensers, temperature-control systems, and parallel reactors.
• Develop and optimize automated downstream processing, including liquid–liquid extraction, solid-phase extraction, filtration, solvent exchange, and parallel evaporation.
• Capture, structure, and integrate experimental and workflow-execution data in ELNs, LIMS, and internal data systems with informatics and computational teams.
• Partner with Analytical Chemistry and Purification groups on integrated workflows for LC-MS/SFC analysis, purification, sample management, and plate-based compound dispatch.
• Evaluate and implement automation technologies, synthetic methodologies, and workflow improvements to increase throughput, reproducibility, data quality, and operational efficiency.
• Provide technical leadership and training to scientists using automated synthesis and HTE platforms, and contribute to laboratory best practices, documentation, and operational standards.