Research Associate Jobs

About The Position

Requirements

• PhD or equivalent in pharmacokinetics, pharmacology, biochemistry, or a related field.
• At least 8 years of industry experience in DMPK or a closely related function.
• Working knowledge of bioanalytical methods, such as LC-MS/MS, ligand binding assays, and NGS, sufficient to oversee method development, qualification, validation, and sample analysis in nonclinical and clinical contexts.
• Demonstrated CRO oversight experience, including vendor qualification, study monitoring, and data review.
• Experience designing and overseeing in vivo nonclinical PK and PK-PD studies for novel delivery modalities.
• Hands-on experience with PK and PK-PD data analysis, such as noncompartmental analysis, and associated software, such as Phoenix WinNonlin, applied to nonclinical and clinical study design and interpretation.
• Experience in translational or clinical biomarker development, including assay strategy and fit-for-purpose qualification.
• Strong scientific writing skills, including regulatory documents such as IND nonclinical sections and internal study reports.
• Experience supervising and developing scientists.

Nice To Haves

• LNP experience.
• Experience in rare disease or genetic medicine.
• Experience with RNA-based therapies.
• Familiarity with LNP platform biology and the delivery landscape.
• Familiarity with GLP toxicology study design and ICH nonclinical guidelines.
• Experience operating in a cross-functional leadership role at a clinical-stage biotech.
• Experience with ligand binding assays and multiplex immunoassay platforms, such as MSD and Luminex, for cytokine, immunogenicity, and biomarker analysis.

Responsibilities

• Lead DMPK strategy and oversee bioanalytical work across nonclinical and clinical programs, including PK, biomarker, and translational PD readouts.
• Oversee development, qualification, and validation of nonclinical and clinical bioanalytical assays, including GLP/GCP-compliant work as required, and associated sample analysis with internal and CRO analytical scientists.
• Design, execute, and oversee PK and PK-PD studies of tRNAs to evaluate delivery technologies, biodistribution, and biomarker effects.
• Lead PK and PK-PD data analysis and interpretation across mouse, rat, NHP, and human studies to support dose selection.
• Manage and qualify CRO and external laboratory partners across bioanalytical and PK programs.
• Support nonclinical toxicology programs in collaboration with internal teams and CROs.
• Analyze, interpret, and present DMPK and translational biomarker data to internal leadership and external stakeholders.
• Author nonclinical sections of regulatory filings, such as INDs, and briefing documents; support agency interactions and responses.
• Serve on the Research Leadership Team and represent DMPK and bioanalytical sciences in cross-functional program discussions.
• Manage and develop direct report(s) and collaborate with the broader pharmacology team.

Benefits

• Healthcare coverage.
• Annual incentive program.
• Retirement benefits.
• A broad range of other benefits.