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Principal Scientist, Biologics Discovery

Johnson & Johnson Innovative MedicineSpring House, PA
Onsite

About The Position

This position is dedicated to advancing the discovery and development of innovative biotherapeutics targeting unmet medical needs through immune-mediated approaches. As a key contributor, you will leverage your expertise in Immunobiology and T-cell biology to support portfolio programs and drive the success of discovery initiatives. You will be responsible for: Leading or actively participating in project teams to progress discovery portfolio projects. Driving technology development efforts for multispecific antibody platforms and validating readiness for portfolio inclusion. Designing, conducting, and interpreting in vitro immune cell functional assays and related experimental studies. Presenting and defending scientific findings independently within multidisciplinary teams and initiatives. Authoring patent applications, manuscripts, study protocols, SOPs, and technical reports. Managing and mentoring scientific staff.

Requirements

  • Ph.D. degree in life sciences (molecular biology, biochemistry, immunology, or a related discipline) with 4+ years post-doctoral experience OR Master’s Degree in life sciences with at least 6+ years of experience is required.
  • Extensive understanding of immunology, including in vitro and in vivo models relevant to immuno-oncology and autoimmune disease.
  • Demonstrated experience with immune cell based assays such as multi-color flow cytometry, cytotoxicity, and multiplex cytokine assays.
  • Experience developing novel, complex, and high-throughput immune assays for functional characterization and MOA studies.
  • Ability to work effectively in a matrixed environment—both within the group and across the broader organization.
  • Strong dedication, motivation, and a collaborative approach to advancing therapeutic innovation.
  • Commitment to continuous learning and scientific excellence.
  • Excellent analytical and problem-solving skills for experimental design and data interpretation.
  • Exceptional communication skills, with the ability to present complex data clearly and concisely is required.

Nice To Haves

  • Experience in end-to-end drug development processes is highly preferred.
  • Industry experience is highly preferred.

Responsibilities

  • Leading or actively participating in project teams to progress discovery portfolio projects.
  • Driving technology development efforts for multispecific antibody platforms and validating readiness for portfolio inclusion.
  • Designing, conducting, and interpreting in vitro immune cell functional assays and related experimental studies.
  • Presenting and defending scientific findings independently within multidisciplinary teams and initiatives.
  • Authoring patent applications, manuscripts, study protocols, SOPs, and technical reports.
  • Managing and mentoring scientific staff.

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What This Job Offers

Job Type

Full-time

Career Level

Principal

Education Level

Ph.D. or professional degree

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