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Senior Associate Scientist, In Vivo Pharmacology,  Oncology

Calyx•Needham, MA
•$52,520 - $97,537•Onsite
Match Resume

About The Position

About Perceptive Our mission is to shape the future of clinical research. With decades of experience and the brightest minds in the industry, we help the global biopharmaceutical industry bring new, advanced medical treatments to market, faster. We seek to change the world, and with the support of our teams across the globe, we flourish together. At Perceptive, we are one team. We learn, grow and win together. Are you ready to help change the world? About the role We are seeking a motivated and skilled Senior Associate Scientist to support validation and execution of our imaging studies using preclinical in vivo oncology- models. This role is central to our preclinical research team and involves building CDx and clinically relevant PDx platforms and hands-on work applying these models with nuclear medicine (PET/SPECT) and computed tomography (CT), MRI, Bioluminescence Imaging. The successful candidate will also provide technical support across a range of in vivo studies including efficacy, biodistribution, pharmacokinetics, tolerability, and dosimetry and ex vivo analysis of target tissues of relevance in oncology, xenograft models.

Requirements

  • Bachelor +5yrs experience OR MS +3yrs experience in Biology, Animal Science or a related field
  • Ability to mentor junior staff
  • Multitasking, organizational and time management skills
  • Comfort with various computer operating systems and programs
  • Strong written and oral communication skills
  • Availability to work some weekends as required
  • Ability to lift 50 pounds

Nice To Haves

  • Ability to perform minor surgical procedures
  • Microdissection of tissues (lymph nodes, specific brain sections, etc)
  • Experience working with anesthesia
  • Experience working with radioactivity
  • Experience working with BSL2 animals and samples
  • Experience with IACUC/Animal Inventory management system (preferably Cayuse)
  • Experience with PET/SPECT/MRI/BLI

Responsibilities

  • Aid in the management of the Animal Care Facility (ACF)
  • Ordering of animals and supplies
  • Sanitization and equipment maintenance
  • Follow, execute and write laboratory specific SOP’s related to role
  • Assess study protocols for experimental details
  • Participate in protocol reviews
  • Lead projects and schedule necessary In-Vivo tasks
  • Meet and determine timelines related to protocol execution
  • Assess animal health conditions, communicate with Attending Veterinarian (AV) and provide necessary animal health care
  • Learn technical/theoretical applications involved in executing pre-clinical studies ​​Cell culture, inoculation, aseptic technique and contamination prevention
  • Proficiency monitoring tumor volume, body weight, clinical signs and model- dependent humane endpoints
  • Maintain clear and concise laboratory notes
  • Perform data quality control and upload relevant documents upon study completion
  • Work with IACUC to implement and ensure compliance of animal use protocols
  • Test article administration IV, IP, SC, IM, PO
  • Perfusion
  • Compound handling
  • Tissue resection
  • Biological sampling procedures
  • Execution of: Efficacy studies, Biodistribution studies, Pharmacokinetic studies, Toxicokinetic studies, Xenograft models
  • Mentor and train new staff
  • Work with radioactive and BSL2 samples and test articles
  • Gamma counting
  • Sample disposition
  • Proper handling and disposal of associated materials
  • Communicate details of your work with scientists and managers
  • Provide husbandry support and routine health checks as needed
  • May assist under supervision in the operation of PET/SPECT/CT/MRI
  • Other duties as assigned

Benefits

  • Medical, Dental and Vision benefits for you and your family, including Flexible Spending Accounts (FSA) and Health Savings Accounts (HSAs)
  • Paid time off policy including holidays and sick time
  • Internal growth and development programs & trainings
  • 401(k) program, life & accident insurance and disability insurance

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What This Job Offers

Job Type

Full-time

Career Level

Senior

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