Scientist 3, CVRM Discovery / Research Biology

Genentech • Daly City, CA

1d • $103,400 - $192,000 • Onsite

About The Position

The CVRM (Cardiovascular, Renal, and Metabolism) Research Biology group within Genentech Research and Early Development (gRED) is seeking a highly talented, motivated, and creative Scientist 3 to investigate novel pathways, targets, and therapeutic development in cardiovascular and kidney diseases. The Scientist 3 contributes to the early-stage CVRM pipeline across multiple therapeutic modalities and disease areas, including obesity, cardiovascular, renal, and metabolic conditions. In this lab-based role, you will work independently and collaboratively to validate new targets and pathways, leveraging in vitro, ex vivo, and in vivo skills. Reporting to the laboratory head and VP of CVRM Research biology, you will engage in target discovery and mechanism-of-action studies while collaborating with cross-functional teams of scientists and clinicians to advance therapeutic development. This is an exciting opportunity to join a growing CVRM biology group and make significant contributions to the early stage pipeline, across multiple tissues and disease areas.

Requirements

• PhD in a life science discipline (e.g., cell biology, biochemistry) or a Bachelor’s degree (with 8+ years) or a Master’s degree (with 6+ years) with equivalent industry experience.
• Demonstrated achievement through high-quality publications and a strong understanding of cardiovascular and metabolic disease biology.
• Skilled in independent, controlled experimental design and literature review to drive mechanism-of-action studies.
• Proficient in culturing mammalian cell lines and primary cells (cardiomyocytes, immune cells, organoids, etc.).
• Experienced in gene manipulation (e.g., CRISPR, shRNA, lentivirus) and characterization of gene expression (e.g., qRT-PCR, RNAseq, Western Blot, ELISA).
• Capable of ex-vivo tissue isolation and downstream processing (e.g., cell isolation, flow cytometry, protein/RNA isolation).
• Competent in plate-reader based assays, reporter assays, dose-response curve generation, and statistical analysis.
• Strong interpersonal skills with the ability to present research in cross-functional forums.

Nice To Haves

• Experience with immunology and cardiovascular physiology.
• Experience, familiarity with cardiovascular models, and experience or willingness to develop in vivo models.
• PhD in a life science discipline (e.g., cell biology, biochemistry) is strongly preferred.

Responsibilities

• Independent design, execution and interpretation of experiments; including brainstorming of next steps and troubleshooting
• Willingness to mentor/cross-train colleagues
• Ability to present research at intra- and inter-departmental meetings
• Communicate findings through high-quality internal presentations, cross-functional forums, and external publications/conferences
• Timely adherence to ELN
• Contribute to and maintain a collaborative lab culture and safe environment

Benefits

• Relocation benefits are available for this job posting.
• A discretionary annual bonus may be available based on individual and Company performance.
• The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior