Senior Scientist, Biology-Discovery

Merck • Upper Gwynedd Township, PA

1d • $117,000 - $184,200 • Onsite

About The Position

We are seeking for an innovative, dedicated and highly motivated Senior Scientist to join the Infectious Diseases and Vaccine Discovery at our company working on infectious and immune-based diseases. Successful candidates will become part of a creative and flexible team that investigates novel therapeutic avenues for infectious and/or immunological diseases using humoral and T cell-based approaches. Candidates for the position will need an understanding of T and B cell biology, innate immunity and cutting-edge methodologies to interrogate specificity and effector functions. Experience in human and NHP immune biology is highly desirable with a proven track record of research accomplishments in academia or industry. Knowledge of immune regulatory pathways in infectious disease and/or other immune diseases will be highly desirable. We are focused on remaining at the forefront of this fast-paced, exciting field and are always looking for innovative ideas. The candidate is expected to carry out laboratory-based work. The candidate will be expected to understand and solve challenging issues independently and to show a high degree of innovation. Critical to success will be the ability to design experiments, interpret and track results, and utilize this information for vaccines and drug development. The candidate must demonstrate well-developed skills for effective communication of scientific information and should have a history of publication(s) in peer-reviewed journals. The candidate is expected to participate in preparation of patents on novel methodology and manuscripts for publication.

Requirements

• MS with at least 5 years of experience, or PhD with at least 2 years of postdoctoral or equivalent industry experience, in (Immunology, Microbiology, Virology), or a related discipline, with relevant experience.
• In-depth knowledge of ELISPOT and ELISA assay execution
• Expertise in multi-parameter flow cytometry and intracellular cytokine staining (ICS) including familiarity with flow cytometry platforms including BD Symphony, LSR II, FACSARIA, and Sony SH800
• Sound understanding of tetramer analysis
• Advanced capability in primary cell culture techniques
• Strong proficiency in cloning and transfection methodologies
• Excellent written and verbal communication skills with the ability to effectively communicate scientific information
• Demonstrated ability to independently understand and solve complex scientific challenges
• High degree of innovation and creative problem-solving skills
• Experience designing experiments, interpreting and tracking results, and applying findings to vaccine and drug development

Nice To Haves

• Proficiency in cytotoxicity assays
• Familiarity with 10X Genomics or other immunoprofiling platforms
• Proficiency in small animal model experimentation and related technical skills
• Track record of publications in peer-reviewed journals
• Experience contributing to patent preparation for novel methodologies
• Experience preparing manuscripts for publication
• Understanding of T and B cell biology, innate immunity and cutting-edge methodologies to interrogate specificity and effector functions.
• Experience in human and NHP immune biology
• Proven track record of research accomplishments in academia or industry.
• Knowledge of immune regulatory pathways in infectious disease and/or other immune diseases

Responsibilities

• Carry out laboratory-based work.
• Understand and solve challenging issues independently.
• Show a high degree of innovation.
• Design experiments, interpret and track results, and utilize this information for vaccines and drug development.
• Effectively communicate scientific information.
• Participate in preparation of patents on novel methodology and manuscripts for publication.

Benefits

• medical, dental, vision healthcare and other insurance benefits (for employee and family)
• retirement benefits, including 401(k)
• paid holidays
• vacation
• compassionate and sick days
• annual bonus
• long-term incentive

What This Job Offers

• Job Type: Full-time
• Career Level: Senior