Scientist Jobs

About The Position

Requirements

• Ph.D. in Neuroscience, Molecular Biology, Genomics, or a related field with a minimum of 3 years of relevant experience in functional genomics, preferably within industry-based CNS drug discovery and development.
• Proficiency in human (Mendelian/population genetics) and model organism genetics
• Expertise in CRISPR-based gene editing techniques, including CRISPR/Cas9, CRISPRa, and CRISPRi.
• Experience with in vivo CRISPR delivery methods such as AAV, lipid nanoparticles, or electroporation for targeting CNS circuits.
• Strong background in neuroanatomy and neurocircuitry, with experience in functional validation of gene edits in preclinical models.
• Proficiency in standard molecular biology and tissue culture techniques, including developing and maintaining CRISPR-edited cell lines.
• Familiarity with in vivo rodent models, behavioral assays, and CNS-relevant phenotypic assessments.
• Strong data analysis and interpretation skills, with experience using bioinformatics tools for genomic analysis.
• Excellent communication and collaboration skills in a cross-disciplinary research environment.

Nice To Haves

• Experience with single-cell RNA sequencing, spatial transcriptomics, or electrophysiological techniques to assess gene function in CNS models.
• Proficiency with computational tools (Python, R, or Unix CLI) for analyzing CRISPR screening data.

Responsibilities

• Design, develop, and execute CRISPR-based functional genomics strategies to validate therapeutic hypotheses in vitro and in preclinical models of CNS diseases.
• Utilize CRISPR/Cas9, CRISPRa, and CRISPRi approaches to modulate gene expression and investigate target biology in the context of neuroanatomy and neurocircuitry.
• Develop and optimize CRISPR delivery methodologies, including viral and non-viral delivery systems, for precise gene editing in the CNS.
• Establish and validate CRISPR-edited rodent models using molecular, cellular, and behavioral readouts to assess target engagement and functional outcomes.
• Collaborate cross-functionally with neuroscience, pharmacology, and translational teams to integrate functional genomics insights into drug discovery programs.
• Perform molecular and cellular assays, including PCR, NGS, immunohistochemistry, and single-cell sequencing, to confirm CRISPR-mediated gene modifications.
• Maintain detailed records of experimental design, execution, and data interpretation in accordance with corporate documentation standards.
• Keep abreast of emerging CRISPR technologies and functional genomics advancements to drive innovation within the team.
• Effectively communicate findings and recommendations to internal and external stakeholders.

Benefits

• annual performance pay bonus