Scientist (52095)

Gap Solutions•Bethesda, MD

19h•Onsite

About The Position

Provide services as a Scientist in support of the overall functions of National Cancer Institute within the National Institutes of Health (NIH). Conduct laboratory-based translational research with a focus on drug development for the treatment of cancer. Initiate, design, and develop new projects or assays that can enable the Center for Cancer Research/Laboratory of U. Rudloff, Rare Tumor Initiative, POB, NCI to fulfill its responsibilities for advance in cancer research and development of cancer diagnostics, cancer drugs, and cancer vaccines. Serve as an authority on the tumor biology that is being studied and the assays that are being performed. Interpret results of initial analysis to reveal conclusions and shortcomings; identify pitfalls in the original choice of methods or experimental direction; redirect the study to achieve improved results. Identify the need for further investigations and/or propose change in direction of work in light of accomplishments, findings, and current and future mission objectives. Work with the scientific staff to define key questions emerging from research projects in which experimental in vitro and in vivo analysis will contribute to elucidation of impact of novel experimental therapeutics on immune cells, cancer cells, and tumors grown in mice in general, mechanisms of cell transformation, identification of molecular targets, and the development of biomarkers/biomarker signatures with potential to guide prevention, diagnosis, or treatment. Collaborate with scientists and statisticians in NCI, NIH, and extramural research institutions as appropriate, to advance the research projects and elucidation of cancer-related data. Collaborate with NIH/NCI expert staff to clarify needs and project objectives. Assists in maintaining adequate space and facilities for ongoing and projected research studies. Attend seminars within the National Institute of Health/Center for Cancer Research/Laboratory of U. Rudloff; pursue additional training, where necessary; participate in discussions at meetings. Make oral presentations at various conferences and seminars. Prepare data sets, Tables and Figures for collaborative papers prepared for publication in peer-reviewed journals; assemble and write papers for first-author publication in peer-reviewed papers. Participate in special committees, panels, and colloquia that meet to determine policy or plan activity in the field.

Requirements

Ph.D. in Biology, Life Sciences or related discipline
Minimum of 2 yrs experience in a laboratory environment
Research experience in immunology and/or molecular biology
Expertise in mouse handling procedures including intraperitoneal intravenous injections, tumor measurements dissections; Immunologic studies including multiparameter flow cytometric processing data analysis as well as in-vitro functional assays including cell culture, stimulation, proliferations, cytokine production.
Expertise in molecular studies techniques including DNA RNA extraction quantification, gel electrophoresis, western blotting, PCR and immunoprecipitation;
Knowledge of proper laboratory techniques, disposal methods, laboratory safety procedures, and universal precautions
Experience in Animal Handling: Mouse
Proficiency in the use of computers and computer programs including expertise in Microsoft Office Suite (MS Word, PowerPoint, Excel)

Nice To Haves

Optical but helpful experience in other techniques include confocal microscopy.
Ability to learn new techniques and teach known techniques to others
Ability to communicate effectively, orally and in writing, with non-technical and technical staff
Detail-oriented and possess strong organizational skills with the ability to prioritize multiple tasks and projects

Responsibilities

Study cultured human and animal cell lines, some of which may be derived from cancer tissue, and analyze human and/or animal tissues with and without cancer.
Perform a wide range of sophisticated genetic, biological, and biochemical assays, including, but not limited to DNA transfection of cells, monolayer and anchorage-independent growth assays, immuno-precipitation assays, agarose gel electrophoresis, and in vivo and in vitro kinase assays.
Perform confocal immune-confocal microscopy of cells
Perform studies that result in technical reports and information to advance cancer research.
Initiate, design, and develop new projects or assays that can enable the Center for Cancer Research/Laboratory of U. Rudloff, Rare Tumor Initiative, POB, NCI to fulfill its responsibilities for advance in cancer research and development of cancer diagnostics, cancer drugs, and cancer vaccines.
Serve as an authority on the tumor biology that is being studied and the assays that are being performed.
Interpret results of initial analysis to reveal conclusions and shortcomings; identify pitfalls in the original choice of methods or experimental direction; redirect the study to achieve improved results.
Identify the need for further investigations and/or propose change in direction of work in light of accomplishments, findings, and current and future mission objectives.
Work with the scientific staff to define key questions emerging from research projects in which experimental in vitro and in vivo analysis will contribute to elucidation of impact of novel experimental therapeutics on immune cells, cancer cells, and tumors grown in mice in general, mechanisms of cell transformation, identification of molecular targets, and the development of biomarkers/biomarker signatures with potential to guide prevention, diagnosis, or treatment.
Collaborate with scientists and statisticians in NCI, NIH, and extramural research institutions as appropriate, to advance the research projects and elucidation of cancer-related data.
Collaborate with NIH/NCI expert staff to clarify needs and project objectives.
Assists in maintaining adequate space and facilities for ongoing and projected research studies.
Attend seminars within the National Institute of Health/Center for Cancer Research/Laboratory of U. Rudloff; pursue additional training, where necessary; participate in discussions at meetings.
Make oral presentations at various conferences and seminars.
Prepare data sets, Tables and Figures for collaborative papers prepared for publication in peer-reviewed journals; assemble and write papers for first-author publication in peer-reviewed papers.
Participate in special committees, panels, and colloquia that meet to determine policy or plan activity in the field.
Work documents and products related to working with laboratory personnel in designing and performing experiments, data analysis and interpretation of results
Work documents and products related to initiating, designing, and developing new projects or assays that can enable the Center for Cancer Research/Rare Tumor Initiative, Dr. U. Rudloff’s Laboratory to fulfill its responsibilities for advance in cancer research and development of cancer diagnostics, cancer drugs, and cancer vaccines
Work products and documents related to performing studies that result in technical reports and information to advance cancer Research
Work products and documents related to working with the scientific staff to define key questions emerging from research projects in which experimental in vitro and in vivo analysis will contribute to elucidation of impact of novel experimental therapeutics on immune cells, cancer cells, and tumors grown in mice in general, mechanisms of cell transformation, identification of molecular targets, and the development of biomarkers/biomarker signatures with potential to guide prevention, diagnosis, or treatment