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Scientist, Data Science

AstraZenecaWaltham, MA

About The Position

We are seeking a highly motivated Scientist to join a newly formed, dynamic team within early oncology R&D. The successful candidate will leverage their data science expertise in mining large datasets to drive our efforts in target identification, mechanism of action (MOA) studies, and biomarker strategy development, with a particular focus on analyses related to the function and aging of the immune system. At AstraZeneca, you'll have the opportunity to make a significant impact on the future of healthcare while working in a collaborative environment at the cutting edge of research. The ideal candidate will thrive in this setting, contributing to our growth trajectory as we build our evolving team.

Requirements

  • Ph.D. in Bioinformatics, Computational Biology, Data Science, Epidemiology, or a related field (0–2 years post-graduate experience); or MS with 2–4 years of experience; or BS with 4+ years of relevant experience.
  • Minimum 2 years of experience working with large-scale biological or population datasets, preferably including experience analyzing immune system aging/function within the context of human and /or mouse data.
  • Strong proficiency in Python or R.
  • Solid understanding of statistical analysis and foundational machine learning techniques.
  • Hands-on experience with NGS data analysis (e.g., RNA-seq, DNA methylation, ChIP-seq, or ATAC-seq).
  • Experience with, or a strong desire to learn, proteomic data analysis and multi-omic data integration.
  • Excellent problem-solving skills, attention to detail, and the ability to manage multiple tasks in a fast-paced environment.
  • Ability to clearly present data and technical workflows to a multidisciplinary team.

Nice To Haves

  • Prior experience or familiarity with biomarkers of immune system aging/function.
  • Prior experience or internship in the pharmaceutical or biotechnology industry.
  • Prior experience running large-scale association testing (e.g., genome-wide association studies [GWAS], epigenome-wide association studies [EWAS], proteome-wide association studies).
  • Familiarity with methods in statistical genetics (e.g., Mendelian randomization, fine mapping, colocalization).
  • Familiarity with machine learning analysis architectures (e.g., random forest, gradient boosting, transformers).
  • Familiarity with public biological databases (e.g., GTEx, TCGA), epidemiological cohort data (e.g., TOPMed cohorts), or biobanks (e.g., UK Biobank, FinnGen).
  • Ability to apply integrated generative protein design pipelines - from target-conditioned backbone generation through sequence design to computational fold validation - to support the development of novel therapeutic biologics with optimized specificity and developability properties.
  • Working knowledge of computational histology pipelines incorporating modern deep learning approaches - including self-supervised and weakly supervised learning (MIL, DINO) and histopathology foundation models (e.g. UNI, CONCH) - to enable scalable, label-efficient classification of complex tissue phenotypes.
  • Familiarity or prior experience with agentic AI in the context of analysis code pipeline development and biological analysis.
  • Evidence of scientific contribution through publications, posters, or GitHub repositories.

Responsibilities

  • Process and analyze large-scale biobank datasets, human population data, and in-vitro biological data using established analysis pipelines.
  • Apply analytical methods and machine learning algorithms to help identify potential therapeutic targets and biomarkers.
  • Partner with wet-lab scientists to analyze experimental results for target identification and Mechanism of Action (MOA) studies.
  • Generate high-quality visualizations and reports to communicate findings to the project team.
  • Provide high-quality data and computational insights that contribute to the development of biomarker strategies.
  • Actively participate in team meetings, presenting data-driven insights to help the group meet project milestones.
  • Stay current with the latest developments in data science and bioinformatics tools.

Benefits

  • Competitive remuneration and benefits apply
  • Competitive Total Reward program including a market driven base salary, bonus and long-term incentive.
  • Generous paid time off program
  • Comprehensive benefits package
  • Eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles.
  • Qualified retirement programs
  • Paid time off (i.e., vacation, holiday, and leaves)
  • Health, dental, and vision coverage in accordance with the terms of the applicable plans.

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What This Job Offers

Job Type

Full-time

Career Level

Entry Level

Education Level

Ph.D. or professional degree

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