Research Scientist Jobs

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Research Scientist

Tabula Bio•San Francisco, CA

About The Position

Tabula is building an AI-first therapeutics company focused on bacteriophages to design therapies for hard-to-treat infections, addressing the growing problem of antibiotic resistance. The company's approach integrates physics-based mathematical modeling and large-scale numerical simulation of phage-bacteria interactions with an in-house wet lab for data generation, calibration, testing, and validation. This unique model generation loop allows for continuous improvement and a shorter path from research to real-world impact. The role is for a computational physicist or equivalent with expertise in numerical methods, large-scale simulation, and complex dynamical systems, who is motivated by challenging technical problems with direct real-world impact.

Requirements

  • A Ph.D. in Physics or a closely related quantitative field (applied mathematics, computational science, or similar), or equivalent research experience.
  • Strong background in numerical methods, large-scale simulation, and the modeling of complex dynamical systems, including systems governed by partial differential equations.
  • Depth in one or more of: statistical mechanics, optimization theory, probabilistic and statistical methods, and numerical stability and error analysis.
  • Experience with large-scale scientific computing and high-performance computing environments.
  • Fluency in Python and the modern scientific-computing stack.
  • Comfort working in an early-stage environment where the problems are hard and the path is still being defined.
  • Ability to work closely with domain experts outside your own field.

Nice To Haves

  • Familiarity with the modern machine learning stack (e.g., PyTorch) is a plus.
  • Substantial modeling and simulation work, not just building products on top of model APIs.
  • Enjoy designing experiments and learning from ambiguous results.
  • Excited by the idea of applying physics and computation to something more concrete than the usual software treadmill.
  • Want work to be tied to outcomes in the real world.
  • Interested in helping build a company where computational and physics-based research is central, not decorative.

Responsibilities

  • Develop physics-based theoretical and computational models of phage–bacteria infection dynamics, applying numerical simulation, statistical mechanics, and optimization theory.
  • Investigate the underlying biophysics of phage infection — binding kinetics, replication dynamics, and population-level interactions — and translate these physical phenomena into tractable mathematical and computational form.
  • Design and implement numerical methods and software for large-scale simulation and analysis of these physical systems.
  • Perform mathematical analysis of the underlying models, including numerical stability analysis, error analysis, and validation against experimental data.
  • Analyze experimental data using mathematical and statistical methods to infer physical parameters and constrain the underlying models.
  • Design and conduct computational experiments, in close coordination with our wet-lab scientists, to test and refine the models.
  • Help define the research roadmap for how Tabula's models should improve over time, and build better practices around experimentation, evaluation, and reproducibility.
  • Help a small team build an AI-first company whose output is not content or software alone, but real therapies for real patients.

Benefits

  • AI-first therapeutics company
  • Addressing antibiotic resistance
  • Physics-based mathematical modeling
  • Large-scale numerical simulation
  • In-house wet lab for data generation
  • Shorter path from research to real-world impact
  • Challenging technical problems
  • Direct real-world impact
  • Room to shape work and direction
  • Opportunity to build a company from the beginning

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What This Job Offers

Job Type

Full-time

Career Level

Senior

Education Level

Ph.D. or professional degree

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