Principal Research Scientist, Analytical Chemistry

IDEAYA Biosciences•South San Francisco, CA

1d•$167,000 - $206,000•Hybrid

About The Position

IDEAYA is a precision medicine oncology company committed to the discovery, development, and commercialization of transformative therapies for cancer. Our approach integrates expertise in small-molecule drug discovery, structural biology and bioinformatics with robust internal capabilities in identifying and validating translational biomarkers to develop tailored, potentially first-in-class, targeted therapies aligned to the genetic drivers of disease. We have built a deep pipeline of product candidates focused on synthetic lethality and antibody-drug conjugates, or ADCs, for molecularly defined solid tumor indications. Our mission is to bring forth the next wave of precision oncology therapies that are more selective, more effective, and deeply personalized with the goal of altering the course of disease and improving clinical outcomes for patients with cancer. When you're at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients. We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person at IDEAYA. We are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use teamwork to move science forward.

Requirements

Ph.D. in analytical chemistry or related discipline with minimum of (5) years of drug discovery experience with demonstrated ability operating successfully within cross-functional groups
Strong subject matter expertise in small molecule purification (both HPLC and SFC essential), physicochemical analysis, analytical method development/validation, and CRO management is essential
Strong problem-solving skills and ability to quickly adapt and shift focus as needed
Strong interpersonal and communication skills and the ability to work within project teams
Ability to multi-task in a fast-paced dynamic environment while demonstrating a calm and positive attitude and a superior work ethic
Ability to supervise and mentor junior level associates and/or scientists, including direct reports or supporting team members
All employees are expected to act with integrity and in full compliance with applicable laws, regulations, and IDEAYA policies, including IDEAYA’s Code of Conduct.
Employees must demonstrate good judgement and ethical behavior in all business activities, maintain patient and product safety as a top priority, and report any suspected violations of law or Company policy through appropriate channels

Nice To Haves

Additional experience with small molecule structural elucidation techniques is preferred

Responsibilities

Oversee small molecule analytical chemistry efforts across the IDEAYA discovery portfolio
Manage and execute compound purifications (including chiral SFC separations), structural elucidations, biophysical property determinations (such as solubility, logD, and pKa determinations), and stability studies
Manage junior analytical chemist(s) to achieve strong productivity with high quality and scientific rigor
Ensure existing methods are technically sound, well developed and fit-for purpose
Troubleshoot methods and provide technical guidance across discovery programs
Manage installation and maintenance of lab analytical equipment.
Perform vendor review and selection and provide oversight of all analytical work at external CROs
Proactively communicate with and work closely with other functions to help align analytical strategy and achieve goals
Help hire high-caliber analytical chemists as needed to build and grow a world-class analytical department
Stay aware of newly emerging techniques and technologies and bring new capabilities online as necessary