Research Scientist Jobs

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Structural Biology Research Scientist

GuidehouseBethesda, MD
Onsite

About The Position

We are seeking a Structural Biology Research Scientist to support the National Institute of Allergy and Infectious Diseases (NIAID) through viral protein construct design, expression optimization, protein purification, and cryo-electron microscopy studies that advance vaccine development. Ideal candidates will bring structural virology experience and skills in assay development, data analysis, reporting, and mentorship. This is a full-time, on-site opportunity in Bethesda, MD.

Requirements

  • PhD in Structural Biology or a related field
  • Microsoft Office
  • Technical experience needed to assist in studying the basic principles of plant and animal life.
  • Technical support and troubleshooting of sophisticated equipment.
  • At least 2 (two) years of experience
  • Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must obtain approved adjudication of their public trust prior to onboarding with Guidehouse.

Nice To Haves

  • Previous experience supporting NIH
  • Candidates with an active public trust or suitability are preferred

Responsibilities

  • Design and generate expression constructs for viral proteins (e.g., envelope glycoproteins, capsid proteins, regulatory proteins).
  • Develop and optimize expression systems (mammalian, insect, or stable cell lines).
  • Purify proteins using chromatography methods (affinity, SEC, ion exchange).
  • Perform binding and antigenicity assays (e.g., ELISA, BLI, SPR).
  • Conduct biochemical and biophysical characterization (e.g., SEC-MALS, DLS).
  • Prepare samples and optimize vitrification conditions for cryo-EM studies.
  • Operate and/or coordinate use of cryo-EM instruments (e.g., Titan Krios, Glacios).
  • Prepare technical reports, figures, and manuscripts.

Benefits

  • Medical, Rx, Dental & Vision Insurance
  • Personal and Family Sick Time & Company Paid Holidays
  • Parental Leave
  • 401(k) Retirement Plan
  • Group Term Life and Travel Assistance
  • Voluntary Life and AD&D Insurance
  • Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
  • Transit and Parking Commuter Benefits
  • Short-Term & Long-Term Disability
  • Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
  • Employee Referral Program
  • Corporate Sponsored Events & Community Outreach
  • Care.com annual membership
  • Employee Assistance Program
  • Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
  • Position may be eligible for a discretionary variable incentive bonus

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What This Job Offers

Job Type

Full-time

Career Level

Senior

Education Level

Ph.D. or professional degree

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