Sr Associate Scientist, Metabolic & Muscle Diseases

Regeneron Pharmaceuticals•Tarrytown, GA

44d•$80,300 - $131,100•Onsite

About The Position

We are seeking a highly motivated and experienced Sr Associate Scientist to join Obesity, Metabolism and Muscle Diseases Group. The individual will serve as a central histological resource, providing expert tissue processing and staining services to multiple Obesity, Metabolism and Muscle Diseases research programs simultaneously. The successful candidate will manage end-to-end histological workflows spanning a broad range of tissue types, maintain rigorous quality standards. This role demands both deep technical proficiency and strong interpersonal skills to navigate competing program demands and deliver high-quality data on time.

Requirements

BS with 5+ years or MS with 2+ years of relevant experience
Proficiency in standard and special histochemical staining techniques across multiple tissue types.
Demonstrated IHC/IF assay development, optimization, and troubleshooting experience
Ability to optimize processing and staining protocols for challenging tissue types or low-abundance samples
Proficiency with whole-slide imaging systems and digital pathology image analysis software (e.g. HALO)
Strong organizational and record-keeping skills
Ability to manage and prioritize simultaneous requests from multiple stakeholders
Excellent oral and written communication skills
Ability to present data at lab meetings

Nice To Haves

Experience with in situ hybridization platforms (RNAscope, BaseScope, FISH) is a plus

Responsibilities

Tissue processing, including tissue fixation, dehydration, clearing, embedding, and sectioning samples from multiple tissue types (e.g., liver, heart, brain, muscle, adipose).
Routine histological staining (e.g H&E, Sirius Red, PAS, Oil Red O) and special staining according to the program needs
Conduct immunohistochemistry (IHC) and immunofluorescence (IF); develop, optimize, and validate new IHC/IF protocols, antibody titrations, and antigen retrieval conditions.
Apply in situ hybridization (ISH/RNAscope) techniques for gene expression localization where required
Perform image aquation, using different scanning platforms (e.g. Aperio, Zeiss Axioscan), and manage image data repositories
Perform quantitative image analysis using platforms such as HALO, develop and apply customized image analysis algorithms
Generate high-quality figures and data summaries suitable for internal reports, regulatory packages, and peer-reviewed publications.
Maintain and communicate a dynamic workload tracker; proactively flag capacity constraints or scheduling conflicts to stakeholders.
Adapt rapidly to shifting program priorities and animal study schedules.
Maintain accurate and complete laboratory records.