Scientist/Senior Scientist, Bioanalytical Sciences (Immunology)

Voyager Therapeutics is seeking a Scientist/Senior Scientist to join their Bioanalytical Sciences team. The ideal candidate will have a strong background in the development of immunological and bioanalytical assays relevant to AAV Gene Therapy and Therapeutic Antibodies. This bench-level position offers the opportunity to work in a cross-functional environment and collaborate with Voyager scientists. The main responsibilities include developing assays, analyzing samples, implementing cutting-edge tools, interpreting data, and collaborating with internal research teams. The candidate will also be involved in the development of standardized procedures and the transfer of methods to CRO labs.

• Develop immunological and bioanalytical assays to assess immune status of preclinical study subjects in AAV gene therapy studies
• Analyze serum and/or plasma samples for the estimation of anti-AAV total antibody (Tab) and neutralizing antibody (Nab) levels
• Identify, evaluate, and implement cutting edge tools and novel immunological methods relevant to AAV gene therapy development
• Independently analyze and interpret data and present in various team formats
• Integrate and collaborate with internal research teams in a fast-paced environment
• Use best practices in the development of standardized procedures and automation systems
• Transfer immunological and bioanalytical methods to CRO labs and monitor method validation and GLP

• Strong background in the development of immunological and bioanalytical assays relevant to AAV Gene Therapy and Therapeutic Antibodies
• Experience in developing immunological and bioanalytical assays to assess immune status of preclinical study subjects in AAV gene therapy studies
• Ability to analyze serum and/or plasma samples for the estimation of anti-AAV total antibody (Tab) and neutralizing antibody (Nab) levels
• Knowledge of cutting-edge tools and novel immunological methods relevant to AAV gene therapy development
• Ability to independently analyze and interpret data and present in various team formats
• Collaboration and integration skills to work with internal research teams in a fast-paced environment
• Familiarity with best practices in the development of standardized procedures and automation systems
• Experience in transferring immunological and bioanalytical methods to CRO labs and monitoring method validation and GLP

• Opportunity to work in a biotechnology company dedicated to breaking through barriers in gene therapy and neurology
• Access to cutting-edge expertise in capsid discovery and deep neuropharmacology capabilities
• Potential to address delivery challenges in gene therapy through the TRACER™ AAV capsid discovery platform
• Fueling alliances with Pfizer Inc., Novartis Pharma AG, Neurocrine Biosciences, Inc., and Sangamo Therapeutics, Inc.
• Wholly owned and collaborative preclinical programs in Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Parkinson’s disease, and other diseases of the central nervous system
• Focus on validated targets and biomarkers to enable a path to rapid potential proof-of-biology
• Opportunity to work in a cross-functional environment and interact with Voyager scientists
• Chance to develop immunological and bioanalytical assays relevant to AAV Gene Therapy and Therapeutic Antibodies
• Access to cutting-edge tools and novel immunological methods
• Opportunity to independently analyze and interpret data and present in various team formats
• Collaboration with internal research teams in a fast-paced environment
• Use of best practices in the development of standardized procedures and automation systems
• Opportunity to transfer immunological and bioanalytical methods to CRO labs and monitor method validation and GLP / GCP sample analyses in those labs
• Opportunity to work with diverse immunoassay platforms including various ELISA formats and functional activity assays
• Chance to develop cell-based assays and enhance cell culture skills
• Opportunity to contribute to multiple parallel workstreams
• Proficiency with Excel, SoftMax Pro, GraphPad Prism, JMP, etc.
• Broad knowledge of Immunology
• Experience in cellular immunity assays such as ELISpot
• Knowledge of Complement activation assays
• Experience in viral gene therapy bioanalytic techniques
• Skills in various PCR techniques
• Experience in GLP and GCLP as applicable to bioanalysis
• Understanding of statistical principles as applicable in bioanalytical data analysis