Vice President, Genome Engineering (Vector Genome)

The Head of Vector Engineering at Voyager Therapeutics will be responsible for developing and implementing a strategic vision and roadmap for gene therapy vector genome research. They will work closely with the Chief Scientific Officer and VP of Novel Capsid Discovery to drive innovation and enhance Voyager's leadership in CNS gene therapy. This role will involve leading a world-class gene therapy engineering organization, managing transgene-related activities, and ensuring the protection and expansion of the company's intellectual property. The Head of Vector Engineering will also play a key role in business development, presenting to stakeholders and overseeing the interrogation and reduction-to-practice of candidate sequences for clinical application.

• Establish and lead the strategic gene therapy AAV vector engineering roadmap and provide exemplary scientific leadership for the company's AAV research programs.
• Recruit, motivate, and develop a world-class, highly innovative gene therapy engineering organization.
• Manage transgene-related activities in discovery research and drive innovation in payload/cargo design.
• Support the continued protection, creation, and expansion of the company's intellectual property.
• Participate in the process of selecting, prioritizing, and accelerating the development of assets.
• Leverage technical opportunities and talent for business advantage and innovation initiatives.
• Play a major role in the company in the area of business development by recommending key initiatives, plans, collaborations, and potential partnerships.
• Present to the company's Board of Directors, Scientific Advisory Board, external stakeholders, and the investment community.
• Responsible for interrogation of candidate sequences and reduction-to-practice of sequences intended for clinical application.
• Work with Research to establish and test constructs in appropriate model systems.
• Ensure data integrity throughout the vector design team, including plasmid nomenclature and archiving.
• Act as a key point of contact with cross-functional stakeholders to ensure suitability and timely manufacture of candidate gene therapy cassettes.

• Strong scientific leadership and expertise in gene therapy AAV vector engineering
• Experience in developing and implementing strategic agendas and roadmaps for gene therapy platforms and programs
• Ability to recruit, motivate, and develop a highly innovative gene therapy engineering organization
• Knowledge of transgene-related activities in discovery research and payload/cargo design
• Familiarity with intellectual property protection and expansion
• Proficiency in selecting, prioritizing, and accelerating the development of assets
• Ability to leverage technical opportunities and talent for business advantage and innovation initiatives
• Experience in business development, including recommending key initiatives, plans, collaborations, and partnerships
• Excellent presentation skills for internal and external stakeholders
• Responsible for interrogation and reduction-to-practice of candidate sequences for clinical application
• Proficiency in establishing and testing constructs in appropriate model systems
• Ensuring data integrity throughout the vector design team
• Collaboration with cross-functional stakeholders for timely manufacture of candidate gene therapy cassettes

• Competitive salary and benefits package
• Opportunity to work in a cutting-edge field of gene therapy and neurology
• Chance to contribute to breakthroughs in the field and address delivery challenges in gene therapy
• Collaboration with leading pharmaceutical companies and academic institutions
• Potential for rapid proof-of-biology and advancement of therapeutic programs
• Access to innovative expertise in capsid discovery and deep neuropharmacology capabilities
• Involvement in the development of the next generation of gene therapy platforms
• Leadership role in identifying and accessing external innovation and strategic collaborations
• Contribution to the protection, creation, and expansion of intellectual property
• Involvement in the selection, prioritization, and acceleration of asset development
• Opportunity to leverage technical opportunities and talent for business advantage and innovation initiatives
• Presentation opportunities to the company's Board of Directors, Scientific Advisory Board, and external stakeholders
• Responsibility for interrogation and reduction-to-practice of sequences for clinical application
• Collaboration with Research for establishment and testing of constructs in appropriate model systems
• Oversight and implementation of high-throughput gene synthesis and expression screening strategies
• Strong interpersonal skills and a team-oriented attitude
• Opportunity to work in a small, entrepreneurial biotech environment with broad responsibilities and opportunities
• Commitment to patient-centricity, transparency, and ethical research values
• Chance to contribute to the advancement of therapeutically oriented AAV gene therapies
• Exposure to an entrepreneurial and science-driven company environment
• Opportunity to drive innovative ways of thinking and using data
• Sophisticated scientific management skills and business judgment