Senior Scientist Jobs

About The Position

Requirements

• Bachelor’s degree in Science or Engineering (Chemistry, Biochemistry, Chemical Engineering, Bioengineering or related field) with 3 years of work experience.
• Experience with using Inductively coupled plasma mass spectrometry (ICP-MS) in bioA method development, qualification and transfer for RLTs.
• Experience with small molecule bioanalysis in various matrices, including blood, tissue and excreta.
• Knowledge of drug ADME principles in understanding PK and biodistribution of small molecule therapeutics.
• Qualified applicants must be authorized to work in the United States on a full-time basis.
• Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.

Nice To Haves

• Experience with discovery and development of radioligand therapeutics (RLT).
• Hands-on experience in sample preparation, LC-MS bioanalytical workflow of RLT in-vivo samples from Cold BioD and IV/PK studies.
• Experience of using ICP-MS (Agilent 8900) is a strong advantage.
• Experience in small molecule bioanalysis, from sample preparation, LC-MS operation, in-vitro or in-vivo metabolism.
• Familiar with MS-related informatic tools to conduct in-depth data analysis.
• Experience with AI-based data analysis and report writing.
• Previous experience in experiment documentation (eLN, signals, benchling, etc.), PK calculation (Phoenix, Watson LIMS, R-studio aNCA), data visualization (PRISM, BioRender) and report QC.
• Hands-on experience in automation or liquid handler instruments, such as Apricot, Hamilton, Tecan and KingFisher to support high-throughput bioanalytical assays.

Responsibilities

• Perform sample preparation (e.g. tissue homogenization, multiwave digestion) and operate mass spectrometer to develop bioanalytical methods and perform quantitative bioanalysis (bioA) of small molecule therapeutics from in-vitro and in-vivo samples.
• Investigate the structure-activity relationship (SAR) including pharmacokinetics (PK), biodistribution (bioD), biotransformation (BioT) and metabolite identification (metID) of drug molecules using LC-MS/MS.
• Collaborate with ADME project leaders to support fast-paced drug discovery projects.
• Serve as bioA representative and provide bioanalytical expertise to project team.
• Maintain and troubleshoot lab instruments to ensure their operation.

Benefits

• company bonus (depending, in part, on company and individual performance)
• company-sponsored 401(k)
• pension
• vacation benefits
• medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)