Research Associate Jobs

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Postdoctoral Research Associate - Developmental Neurobiology

St. Jude Children's Research HospitalMemphis, TN
Onsite

About The Position

A postdoctoral position is available in the laboratory of Dr. Young-Goo Han in the Department of Developmental Neurobiology/Neurobiology and Brain Tumor Program at St. Jude Children’s Research Hospital. The Han laboratory studies the biology of primary cilia and how cilia-dependent signaling regulates cell behavior in normal development and disease, with particular emphasis on brain development, brain tumors, neurodevelopmental disorders, and neurodegenerative diseases. The Han laboratory has made important contributions to understanding the roles of primary cilia and Hedgehog signaling in neural stem cell formation, cerebellar development, medulloblastoma, neocortical growth and folding, and cilia-dependent regulation of translation and the cell cycle. Applicants who are interested in fundamental mechanisms by which primary cilia or mitochondria control cellular homeostasis and signaling are encouraged to apply. We use a broad range of approaches, including human pluripotent stem cells, brain organoids, genome editing, high-resolution imaging, single-cell sequencing, spatial transcriptomics, epigenomics, and proteomics, as well as a unique mouse model in which neural progenitors acquire key features of human neural progenitors, driving expansion and folding of the normally small, smooth mouse cortex. Research areas may include: Primary cilia and compartmentalized signaling, Cell and molecular mechanisms of cilia function, Mitochondrial homeostasis, Brain development and neural progenitor biology, Brain tumor biology, Neurodevelopmental and neurodegenerative disorders.

Requirements

  • Ph.D., M.D., or equivalent degree.
  • Strong background in cell biology, molecular biology, developmental biology, neuroscience, cancer biology, neurodegeneration, or a related field.
  • Highly motivated candidates with strong communication skills.
  • A record of scientific productivity.

Nice To Haves

  • Experience in primary cilia biology.
  • Experience in mitochondrial homeostasis.
  • Experience in mouse genetics.
  • Experience in imaging.
  • Experience in biochemistry.
  • Experience in genomics.
  • Experience in stem/progenitor cell biology.
  • Experience in disease models.

Responsibilities

  • Study the biology of primary cilia and how cilia-dependent signaling regulates cell behavior in normal development and disease.
  • Focus on brain development, brain tumors, neurodevelopmental disorders, and neurodegenerative diseases.
  • Investigate fundamental mechanisms by which primary cilia or mitochondria control cellular homeostasis and signaling.
  • Utilize approaches including human pluripotent stem cells, brain organoids, genome editing, high-resolution imaging, single-cell sequencing, spatial transcriptomics, epigenomics, and proteomics.
  • Work with a unique mouse model to study neural progenitor behavior.
  • Conduct research in areas such as primary cilia and compartmentalized signaling, cell and molecular mechanisms of cilia function, mitochondrial homeostasis, brain development and neural progenitor biology, brain tumor biology, and neurodevelopmental and neurodegenerative disorders.

Benefits

  • Outstanding and highly collaborative research environment.
  • Exceptional core facilities.
  • Strong support for postdoctoral training and career development.

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What This Job Offers

Job Type

Full-time

Career Level

Mid Level

Education Level

Ph.D. or professional degree

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