Scientist, Protein Sciences

Systimmune • Bothell, WA

1d • $90,000 - $115,000 • Onsite

About The Position

SystImmune is seeking a Scientist to join its Antigen Science team in Bothell, Washington. The role focuses on designing, expressing, and purifying recombinant antigens to support antibody discovery and engineering programs. The Scientist will apply molecular biology expertise and mammalian expression experience to produce high-quality reagents, work with colleagues in discovery and assay development to meet program needs, and exercise independent judgment in construct design, expression optimization, and purification. The position is full-time and onsite.

Requirements

• PhD in Biochemistry, Molecular Biology, or a related field.
• For PhD candidates, 0–3 years of industry or postdoctoral experience.
• Strong hands-on experience with recombinant protein purification technologies.
• Strong hands-on experience with molecular biology techniques, including plasmid construction and sequence analysis.
• Demonstrated experience with mammalian cell culture and recombinant protein expression, including transient transfection and stable cell line development.
• Ability to work independently and troubleshoot experimental problems.
• Clear written and verbal communication skills and a collaborative approach to cross-functional work.

Nice To Haves

• Experience with antibody discovery, immunization, or screening workflows.
• Experience with high-throughput or automated expression and purification platforms.
• Publications in peer-reviewed journals.

Responsibilities

• Design and clone antigen constructs using molecular biology techniques, including vector design, cloning strategies, and sequence verification.
• Develop and optimize transient and stable mammalian expression systems, such as HEK293 or CHO, to produce secreted and cell-surface antigens.
• Establish and execute recombinant protein purification workflows, including affinity, ion-exchange, and size-exclusion chromatography.
• Troubleshoot expression and purification problems by adjusting constructs, culture conditions, and purification strategies.
• Establish and execute quality control for each antigen batch, including assessment of purity, identity, and homogeneity.
• Partner with antibody discovery, engineering, and assay development colleagues to understand reagent requirements and deliver accordingly.
• Maintain detailed records, present results to the team and cross-functional partners, and contribute to technical reports, publications, and patent applications.

Benefits

• 100% paid employee premiums for medical, dental, and vision insurance.
• Short-term disability insurance.
• Long-term disability insurance.
• 401(k) plan with a 50% company match of up to 3%, with a five-year vesting schedule.
• 15 PTO days per year.
• Sick leave.
• 11 paid holidays.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree