Associate Scientist II, Protein Sciences

Alnylam Pharmaceuticals•Cambridge, MA

6d•$67,600 - $101,400•Onsite

About The Position

Alnylam is seeking an Associate Scientist II to join its Protein Sciences team and contribute to protein production and conjugation efforts. The role supports protein and protein-conjugate delivery and validation at various production scales, as well as discovery research across multiple therapeutic modalities. The successful candidate will work with some guidance on project-related scientific activities and collaborate with cross-functional teams of biologists, chemists, and pharmacologists. This is a lab-based, onsite position in Cambridge, Massachusetts.

Requirements

BS or MS degree in chemistry, chemical engineering, biochemistry, or a related field.
0–1 years of relevant laboratory experience in a biopharma or academic setting.
Experience with modern bioconjugation chemistry and analytical techniques.
Experience with instrumentation such as Agilent and ÄKTA HPLC systems, TFF, and UV–Vis spectrometry.
Experience analyzing proteins and protein conjugates using techniques such as affinity chromatography, SEC, RP-HPLC, HIC, IEX, SDS-PAGE, and UV–Vis spectroscopy.
Passion for driving projects from the bench, independently contributing to research goals, and solving challenging problems.
Detail-oriented and self-motivated, with comfort working on highly technical projects in a multidisciplinary team setting.
Effective written and oral communication skills.

Nice To Haves

Experience developing new chromatographic methods.

Responsibilities

Work with the Protein Sciences team to deliver and validate proteins and protein conjugates at various production scales.
Design, plan, and perform protein-conjugation experiments supporting in vitro and in vivo evaluations, and contribute to project-related scientific activities with some guidance.
Support purification, buffer exchange, characterization, and quality control of protein and oligonucleotide conjugates using UV–Vis spectroscopy and HPLC.
Contribute to the maintenance of laboratory infrastructure and equipment.
Support group organization, productivity, and expertise through collaboration and idea exchange.
Assist in optimizing the inventory system for proteins and protein conjugates.
Meet quality, quantity, and timeline expectations for assigned projects.
Support discovery efforts in protein sciences.
Maintain accurate and complete electronic notebook records.
Communicate experimental plans and data to cross-functional scientific teams.