Senior Research Associate, Protein Sciences

Systimmune • Bothell, WA

1d • $70,000 - $90,000 • Onsite

About The Position

SystImmune is seeking a Senior Research Associate to join its Antigen Science team as a core technical resource. The role supports antibody discovery, engineering, and assay development through day-to-day antigen production, including expression, purification, plasmid DNA scale-up, and routine quality control. The position executes established workflows reliably and with high quality, helping ensure reagent production stays on schedule for colleagues across discovery and assay development. This is an onsite role in Bothell, Washington.

Requirements

• BA in Biology, Biochemistry, Molecular Biology, or a related field and at least 5 years of industry experience in protein production, or an MS in a related field and at least 3 years of industry experience.
• Hands-on experience with recombinant protein expression and purification, including mammalian cell culture and transient transfection.
• Practical experience with plasmid DNA preparation and scale-up.
• Proficiency with routine protein analysis, including SDS-PAGE and Western blotting.
• Working knowledge of affinity, ion-exchange, and size-exclusion chromatography on FPLC or similar systems.
• Ability to manage multiple tasks and priorities in a fast-paced team environment.
• Clear written and verbal communication skills and a collaborative approach to cross-functional work.

Responsibilities

• Purify antigens using affinity, ion-exchange, and size-exclusion chromatography on FPLC or similar systems, following established protocols.
• Scale up plasmid DNA preparations to support expression campaigns while ensuring quality and yield.
• Perform recombinant antigen expression in mammalian cells, including transient and stable expression.
• Conduct routine antigen quality control, including SDS-PAGE, Western blotting, and other standard analytical assays; record and report results.
• Maintain detailed and accurate laboratory records, inventory, and reagent batch documentation.

Benefits

• 100% paid employee premiums for medical, dental, and vision insurance.
• Short-term disability insurance.
• Long-term disability insurance.
• 401(k) plan with a 50% company match of up to 3%, with a 5-year vesting schedule.
• 15 PTO days per year.
• Sick leave.
• 11 paid holidays.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior