Scientist II/Senior Scientist I, DMPK

Zealand Pharma • Cambridge, MA

4d

About The Position

Zealand Pharma is expanding its global R&D capabilities and establishing research units in Cambridge, Massachusetts, to advance drug modality capabilities in metabolic disease. The Scientist II/Senior Scientist I will play a central role in the DMPK group, advancing LC-MS capabilities and DMPK science for complex molecular formats. This role offers broad responsibilities and an opportunity to help build a new platform and research center from an early stage.

The position is part of the Global DMPK department within Pharmacokinetics, Immunogenicity and Bioanalytical Sciences. The scientist will work closely with cross-functional R&D stakeholders, including Discovery, Translational, Toxicology, Clinical Pharmacology and Regulatory, to shape study strategies, interpret data, and communicate DMPK risks and recommendations.

Zealand Pharma is a biotechnology company focused on medicines for obesity and metabolic health, combining peptide R&D expertise with a data platform using data-driven and AI/ML approaches. The company is headquartered in Copenhagen, Denmark, and has a U.S. presence in Cambridge, Massachusetts.

Requirements

• Ph.D. in pharmaceutical sciences, biochemistry, analytical chemistry, chemistry or a related scientific field with 0–3 years of relevant industry or postdoctoral experience; or M.S. with approximately 3–6 years of relevant industry experience; or B.S./B.A. with approximately 5–8+ years of relevant industry experience.
• Solid hands-on background in LC-MS bioanalysis and assay development.
• Strong technical expertise across the full LC-MS bioanalysis and PK workflow.
• Scientific curiosity and sound judgment.
• Ability to communicate scientific data and concepts clearly and work effectively across cross-functional project teams.
• Enjoys working in a collaborative, multidisciplinary environment and is motivated to help shape a new platform and research center from an early stage.

Nice To Haves

• Experience in PK study design, data interpretation and translating DMPK insights into actionable project recommendations.
• Experience with bioanalysis of complex molecules such as peptides, antibodies and conjugates.
• Familiarity with ADME assays and metabolite identification for larger molecules.
• Experience with digital or automation-enabled bioanalysis and DMPK workflows.

Responsibilities

• Contribute to developing DMPK discovery platforms and bioanalysis capabilities for complex drug modalities, such as antibodies, antibody-peptide conjugates and peptides.
• Execute the LC-MS bioanalysis workflow, from input to PK study design through method development, sample analysis and reporting PK and exposure data.
• Support PK and metabolite identification across discovery projects.
• Design and conduct in vitro assays, such as metabolic stability experiments and other project-relevant DMPK assays.
• Contribute to continuous improvement by adopting efficient, digital and automation-enabled approaches within DMPK workflows.
• Work with cross-functional R&D stakeholders to shape study strategies, interpret data, and communicate DMPK risks and recommendations.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level