Senior Scientist I/II, Oncology
About The Position
The xDC Biotherapeutics group within Oncology Drug Discovery at Novartis Biomedical Research is seeking a highly motivated and collaborative Senior Scientist I/II to advance drug-conjugate discovery programs for cancer treatment. This lab-based role applies cell and molecular biology techniques to generate data for target validation and drug optimization. It requires strong understanding and experience with in vitro cell-based assays for drug discovery. The successful candidate collaborates with colleagues across Biomedical Research and contributes to multidisciplinary project teams, supporting the advancement of biotherapeutic drug discovery projects into the Novartis portfolio. The role is based in Cambridge, Massachusetts, and cannot be performed remotely. This listing represents multiple openings; the final level and title will be determined by the hiring team based on skills, experience, and capabilities.
Requirements
- BS or MS degree in biology or a related field.
- Extensive experience with cellular assay development and execution.
- Ability to analyze, interpret, and clearly present data and use data to generate new hypotheses.
- Highly self-motivated and collaborative, with exceptional organizational skills and curiosity to expand and diversify skillsets.
Nice To Haves
- A minimum of 5+ years of industry experience is preferred.
- Experience with high-throughput screening workflows is strongly preferred.
- Oncology experience is highly preferred.
- Understanding of drug discovery optimization processes.
- Experience with discovery of antibody-drug conjugates.
Responsibilities
- Generate hypotheses, troubleshoot issues, and design and execute experiments with some input from senior lab members or a manager.
- Independently and collaboratively design, execute, and analyze in vitro experiments to profile small molecules and biologics and elucidate mechanisms of action.
- Execute cell and molecular biology assays, including CellTiter-Glo, flow cytometry, JESS, western blot, and MSD.
- Culture cells using sterile technique, including genetic engineering and validation of cell lines.
- Use laboratory automation equipment, including liquid handlers, plate readers, and dispensers, to perform screens.
- Maintain organized and detailed records of experiments.
- Collaborate across teams and train team members in areas of technical expertise as needed.
- Communicate findings clearly and present research to multidisciplinary project teams.
- Support lab operations, including materials management, instrument maintenance, and general laboratory duties.
Benefits
- Health benefits
- Life benefits
- Disability benefits
- 401(k) with company contribution and match
- Vacation, personal days, holidays, and other leaves
- Performance-based cash incentive
- Depending on role level, eligibility to be considered for annual equity awards
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What This Job Offers
Job Type
Full-time
Career Level
Senior
