Senior Scientist I/II, Oncology
About The Position
The xDC Biotherapeutics group within Oncology Drug Discovery at Novartis Biomedical Research is seeking a highly motivated and collaborative Senior Scientist to advance drug-conjugate discovery programs for cancer treatment. This onsite, lab-based role in Cambridge, Massachusetts applies cell and molecular biology techniques to generate data for target validation and drug optimization. The role requires a strong understanding of in vitro cell-based assays for drug discovery and involves collaboration with colleagues across Biomedical Research as part of multidisciplinary project teams. The scientist will support discovery of biotherapeutics and the advancement of drug-discovery projects into the Novartis portfolio. This listing represents multiple openings for the same role; the final level and title will be determined by the hiring team based on skills, experience, and capabilities.
Requirements
- BS or MS degree in biology or a related field.
- Extensive experience with cellular assay development and execution.
- Ability to analyze, interpret, and clearly present data, and use data to generate new hypotheses.
- Highly self-motivated and collaborative, with strong organizational skills and curiosity to expand and diversify skillsets.
Nice To Haves
- Minimum 5+ years of industry experience preferred.
- Experience with high-throughput screening workflows strongly preferred.
- Oncology experience highly preferred.
- Understanding of drug discovery optimization processes.
- Experience with discovery of antibody-drug conjugates.
Responsibilities
- Generate hypotheses, troubleshoot issues, and design and execute experiments, with some input from senior lab members or the manager.
- Design, execute, and analyze in vitro experiments independently and as part of a team to profile small molecules and biologics and elucidate mechanisms of action.
- Execute cell and molecular biology assays, including CellTiter-Glo, flow cytometry, JESS, western blot, and MSD.
- Culture cells using sterile technique, including genetic engineering and validation of cell lines.
- Use laboratory automation equipment, including liquid handlers, plate readers, and dispensers, to perform screens.
- Maintain organized and detailed records of experiments.
- Collaborate across teams and train team members in areas of technical expertise as needed.
- Communicate findings clearly and present research to multidisciplinary project teams.
- Support lab operations, including management of materials, instrument maintenance, and general laboratory duties.
Benefits
- Performance-based cash incentive.
- Depending on role level, eligibility to be considered for annual equity awards.
- Health, life, and disability benefits for eligible US-based employees.
- 401(k) with company contribution and match.
- Vacation, personal days, holidays, and other leaves.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
