Scientist I - In Vivo Pharmacology

Novo Nordisk•Lexington, MA

10h•Onsite

About The Position

The Scientist I position is within the Diabetes Discovery Pharmacology team in the Diabetes Research US research area, based in Lexington. This role requires a strong background in diabetes and metabolism research, with the candidate being a self-motivated team player possessing strong communication skills. The Scientist I will manage multiple activities concurrently, demonstrate a collaborative mindset, and exhibit strong personal drive and dedication. A flexible attitude and the ability to adapt to changing project priorities are essential. The primary responsibility is to implement strategies and operations for conducting and summarizing non-clinical in vivo studies, both internally and externally, to support the evaluation of new drugs for the Diabetes research pipeline. This includes designing, coordinating, executing, and reporting pre-clinical pharmacokinetic and pharmacodynamic in vivo experiments and associated endpoints for target validation, maturation, or mode-of-action studies. The role also involves developing and improving in vivo models, optimizing and developing necessary assays for endpoint analyses, actively participating in research projects, and contributing to innovation by identifying and exploring new therapeutic targets and principles. The Scientist I will communicate data evaluations and implications internally, externally, and in regulatory submissions, occasionally demonstrating subject matter expertise and being perceived as an area specialist. The individual will handle most situations independently, seeking guidance on more complex issues, and demonstrate the ability to identify and create improvements in methods and techniques. They may work independently or with occasional guidance from a manager/senior colleagues and may mentor junior colleagues. Hands-on work with complex activities is expected, potentially leading experiment teams, providing guidance on experimental strategies, setting study timelines, communicating study updates, and generating, analyzing, and reporting data. The role may involve representing the team at external conferences, drafting reports and protocols with limited assistance, participating in external collaborations, and recommending targets or new methodologies. Mentoring or supervising less experienced team members may also be required.

Requirements

BS/BA Degree with 6+ years’ relevant experience required, or a master’s degree with 4+ years’ relevant experience, or a Doctoral degree with limited to no experience
Experience in conducting and summarizing non-clinical in vivo studies
Strong knowledge and experience in pre-clinical pharmacokinetic and pharmacodynamic in vivo experiments
Proven ability to develop and improve in vivo models supporting non-clinical studies
Experience in communicating and presenting in vivo data internally, externally, and in regulatory submissions
Familiarity with drug discovery processes and target validation
Demonstrated critical thinking and problem-solving skills in a scientific research setting
Strong background in diabetes and metabolism research
Self-motivated team player with strong communication skills
Ability to manage multiple activities in parallel
Collaborative mind-set with a strong personal drive and dedication
Flexible attitude and the ability to change focus as required by the projects and shifting priorities

Nice To Haves

May mentor or directly supervise less experienced team members based on business need, skill, and/or interest.

Responsibilities

Design, coordinate, execute and report pre-clinical pharmacokinetic and pharmacodynamic in vivo experiments and associated endpoints within research projects as part of target validation, target maturation, or mode-of-action studies.
Develop and improve in vivo models supporting non-clinical studies, optimize and develop assays necessary for endpoint analyses.
Take an active role in research projects, and contribute to innovation by identifying and exploring new therapeutic targets and principles.
Communicate evaluations and implications data packages internally, externally, and in regulatory submissions as relevant.
Conduct and summarize non-clinical in vivo studies including study endpoints.
Implement strategies for conducting and summarizing non-clinical in vivo studies and associated analyses.
Ensure the proper execution and documentation of all experiments.
Analyze and interpret data to draw meaningful conclusions and recommendations.
Design and coordinate pre-clinical pharmacokinetic and pharmacodynamic experiments.
Collaborate with research projects to design and coordinate pre-clinical in vivo experiments.
Ensure adherence to ethical and regulatory guidelines in the design and execution of experiments.
Coordinate with internal and external stakeholders to ensure smooth execution of experiments and data generation and collection.
Develop and improve in vivo models, in vitro and ex vivo assays supporting non-clinical studies.
Identify opportunities to develop and improve models and assays for non-clinical studies.
Conduct literature reviews and stay up-to-date with advancements in in vivo models, laboratory techniques, diabetes and metabolism research.
Collaborate with cross-functional teams to implement new and refine existing methodologies.
Communicate evaluations and implications data.
Prepare and deliver presentations data evaluations and implications.
Collaborate with internal teams to help prepare regulatory submissions as applicable.
Engage with external stakeholders to share in vivo data and insights, fostering collaboration and partnerships.