Scientist I - In Vivo Pharmacology

Novo Nordisk•Lexington, MA

8h•Onsite

About The Position

The Scientist I is expected to have a strong background in diabetes and metabolism research and be a self-motivated team player with strong communication skills. The Scientist I will be expected to manage multiple activities in parallel and have a collaborative mindset with a strong personal drive and dedication. This position requires a flexible attitude and the ability to change focus as required by the projects and shifting priorities. The Scientist I will be responsible for strategy implementation and operational execution of non-clinical in vivo studies, conducted internally and externally, to support our Diabetes research pipeline. The role involves designing, coordinating, executing, and reporting pre-clinical pharmacokinetic and pharmacodynamic in vivo experiments, along with associated endpoints, as part of target validation, target maturation, or mode-of-action studies. The Scientist I develops and refines in vivo models to support non-clinical studies, optimizes and establishes assays for endpoint analyses, and actively contributes to research projects by driving innovation through identification and evaluation of new therapeutic targets and approaches. In addition, the Scientist I operates effectively as a collaborative team member within a matrixed environment, partnering cross-functionally with internal stakeholders and external collaborators to ensure alignment on study design, execution, and interpretation. The role requires strong communication and teamwork skills to integrate diverse perspectives, facilitate decision-making, and advance project objectives. The Scientist I communicates the evaluation and implications of in vivo data packages clearly and effectively to internal teams, external partners, and in regulatory submissions, as appropriate. Occasionally demonstrates subject matter expertise. Perceived as area specialist within one or several processes across a VP/CVP area. Often sets directions and deliver results in own role which have a significant impact within the context of a wider operational area. Applies subject matter knowledge to solve common business issues. Handles most situations independently and with routine, receives minimal guidance, but will seek advice and guidance on more complex issues. Demonstrated ability to identify better practice and create improvements in methods, techniques, approaches etc. Might be entirely independent or just need occasional guidance from manager/senior colleagues and may mentor/coach more junior colleagues. Hands-on work involving highly complex activities; may lead experiment teams comprising colleagues from different areas to support project goals; provides guidance regarding experimental strategies; responsible for setting study timelines to meet project deliverables, communicating study updates, & data generation, analyses, & reporting; may represent team or project at external conference; responsible for drafting reports & protocols with limited assistance from supervisor beyond reviews; may actively participate in external collaborations; may recommend targets or new biologies or methodologies. May mentor or directly supervise less experienced team members based on business need, skill, and/or interest.

Requirements

BS/BA Degree with 6+ years’ relevant experience required, or a master’s degree with 4+ years’ relevant experience, or a Doctoral degree with limited to no experience
Experience in conducting and summarizing non-clinical in vivo studies
Strong knowledge and experience in pre-clinical pharmacokinetic and pharmacodynamic in vivo experiments
Proven ability to develop and improve in vivo models supporting non-clinical studies
Experience in communicating and presenting in vivo data internally, externally, and in regulatory submissions
Familiarity with drug discovery processes and target validation
Demonstrated critical thinking and problem-solving skills in a scientific research setting

Responsibilities

Conduct and summarize non-clinical in vivo studies including study endpoints
Implement strategies for conducting and summarizing non-clinical in vivo studies and associated analyses
Ensure the proper execution and documentation of all experiments
Analyze and interpret data to draw meaningful conclusions and recommendations
Design and coordinate pre-clinical pharmacokinetic and pharmacodynamic experiments
Collaborate with research projects to design and coordinate pre-clinical in vivo experiments
Ensure adherence to ethical and regulatory guidelines in the design and execution of experiments
Coordinate with internal and external stakeholders to ensure smooth execution of experiments and data generation and collection
Develop and improve in vivo models, in vitro and ex vivo assays supporting non-clinical studies
Identify opportunities to develop and improve models and assays for non-clinical studies
Conduct literature reviews and stay up to date with advancements in in vivo models, laboratory techniques, diabetes and metabolism research
Collaborate with cross-functional teams to implement new and refine existing methodologies
Communicate evaluations and implications data
Prepare and deliver presentations data evaluations and implications
Collaborate with internal teams to help prepare regulatory submissions as applicable
Engage with external stakeholders to share in vivo data and insights, fostering collaboration and partnerships

Benefits

company bonus based on individual and company performance
long-term incentive compensation
company vehicles depending on the position's level or other company factors
medical, dental and vision coverage
life insurance
disability insurance
401(k) savings plan
flexible spending accounts
employee assistance program
tuition reimbursement program
voluntary benefits such as group legal, critical illness, identity theft protection, pet insurance and auto/home insurance
time off pursuant to its sick time policy
flex-able vacation policy
parental leave policy