Scientist I, In Vivo Pharmacology
About The Position
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. Our expanding In Vivo Tumor Biology group is hiring a motivated tumor biologist dedicated to discovering and developing innovative small-molecule and biologic therapeutics. The position will focus on tumor-targeting biologics including ADCs and T-cell engager (TCE) therapeutics in both immunocompromised and humanized mouse models. Our scientists collaborate with in vitro biology, translational/biomarker, and medicinal chemistry teams to advance oncology agents through the R&D pipeline. The position is within a dynamic, collaborative research team passionate about advancing novel science and improving patients' lives.
Requirements
- BS with 5+ years of experience or MS 2+ years with a degree in physiology, pharmacology, molecular biology or any related field of biology is required.
- Strong technical expertise in in vivo experimentation, including health monitoring, tumor implantation (subcutaneous, disseminated etc.), tumor measurements, dosing via IP, IV, SC, PO routes, and blood/tissue collection.
- Excellent communication skills and a willingness to work with a multidisciplinary team of researchers are essential.
Nice To Haves
- Familiarity with huPBMC and CD34 humanized mice is highly desired.
- Experience with mouse models of cancer, including CDX and/or PDX xenograft models is preferred.
- Familiarity with data analysis, presentation, data management, and statistical software (e.g. Microsoft Office, Study Director, GraphPad Prism) is a plus.
- Grounding in ADC or TCE therapeutics is desired.
- Strong candidates have experience in ADC and TCE therapeutics and familiarity with humanized mouse studies.
Responsibilities
- Independently execute, monitor, and interpret in vivo mouse cancer studies (e.g. CDX, PDX, disseminated, syngeneic)
- Evaluate novel cancer therapeutics in vivo through efficacy, PK, and tolerability studies.
- Collect and prepare tissue from in vivo tumor studies for PD analysis in downstream applications, including IHC, flow cytometry, and RNAseq
- Identify, validate and utilize humanized mouse models to support Abbvie pipeline assets.
- Interpret results and draw conclusions from own multistage experiments and suggest, design, and pursue relevant experiments that further project goals.
- Perform routine and complex tasks competently and independently.
- May innovate new experimental protocols/techniques.
- Appetite for developing novel in vivo approaches and models to address complex biological questions.
Benefits
- paid time off (vacation, holidays, sick)
- medical/dental/vision insurance
- 401(k)
- short-term incentive programs
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
