Senior Associate Scientist, In Vivo Pharmacology, Oncology Discovery Biology

Bristol Myers Squibb • Cambridge Crossing, VA

2d • $105,040 - $127,287 • Onsite

About The Position

The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area. Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.

Position Summary: The successful candidate will join the Oncology Discovery Pharmacology and In Vivo Biology group at Bristol-Myers Squibb in Cambridge, MA and aid in the advancement of early-stage therapeutics in Oncology TRC. This role provides an opportunity to work on cutting-edge immuno-oncology programs, including T cell engager platforms, and to directly impact early-stage therapeutic development. The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to advance preclinical drug development programs from target identification/validation through IND enabling activities. The candidate will be expected to effectively collaborate with colleagues in Discovery Oncology, protein engineering/antibody development, DMPK and translational group. The successful candidate will demonstrate clear and professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams and key stakeholders.

Requirements

• Bachelor’s Degree 4+ years of academic and / or industry experience Or Master’s Degree 2+ years of academic and / or industry experience
• A B.S. with 2-7 years relevant industry or comparable academic experience and a clearly demonstrated in vivo and ex vivo oncology skill sets are required.
• Experience with subcutaneous syngeneic and xenograft tumor models is required
• Competency in murine dosing IV, IP, SC & PO, is required
• Proficiency in cell culture, passaging and harvesting, preparing adherent and suspension mammalian cells for subcutaneous and intravenous implantation is required.
• Experience in independently processing blood samples, harvesting and disaggregating tumors, spleen, and lymph nodes, and preparing samples for FACS analysis.
• Experienced in setting up basic FACS multichannel panels (5-6 color) and routinely profile tumors, blood and lymphoid organs by Flow cytometric analysis.
• Familiar with cytokine profiling studies and analysis by MSD & Luminex methods.
• Proficiency in utilizing software such as GraphPad Prism™, electronic notebooks, Microsoft office etc. for data analysis and figure generation is required.
• Excellent organizational skills and a detail-oriented approach to the execution of experiments and record keeping is a requirement.
• Strong interpersonal skills with the ability to interact effectively with peers and management is required.

Nice To Haves

• experience with orthotopic, chemically induced mouse models, GEMMs, and PDx models are all preferred.
• intra-tumor and IM is preferred.
• Rodent surgical experience is a plus.

Responsibilities

• Experience in conducting mouse in vivo pharmacology experiments, including but not limited to model development, tumor implantation, dosing via IV, IP, SC, IT, IM, and PO routes, tumor measurements, health monitoring, tissue sampling by tail vessel micro-sampling, cardiac puncture and tissue/tumor collection at necropsy including fixation, freezing and tissue disaggregation to support ex vivo analyses.
• Collaborate with the team to conduct in vivo efficacy and PK/PD studies and experiments supporting the development of new pharmacology models.
• Independently execute end-to-end flow cytometry workflows, encompassing panel design and establishment, multiparametric profiling of blood, tumor, and lymphoid tissues, downstream data analysis, and clear communication of results to cross-functional teams.
• Isolate PBMC and primary T cells from Leukopaks and functionally characterize them using cell-based assays.
• Accurately maintain proper scientific documentation associated with pharmacology studies in an electronic lab notebook.
• Effectively communicate and present summaries of research results to team members or to a multidisciplinary team of researchers.

Benefits

• Medical, pharmacy, dental, and vision care.
• Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
• 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
• unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior