Senior Scientist, Hemes in vivo pharmacology

AstraZeneca • Waltham, MA

1d • $116,284 - $174,426 • Onsite

About The Position

We are seeking a highly motivated and independent Senior Scientist with experience in hematology oncology and a track record of scientific excellence to join our team in Waltham, MA, USA. As a Senior Scientist, you will be leading hands-on research to evaluate the efficacy and mechanisms of small molecules in hematology oncology. You will utilize your cancer biology experience and in vivo expertise to generate robust pharmacology datasets that will have a direct impact on the oncology drug discovery pipeline.

Requirements

• PhD with 3+ yrs research experience in academia, biotechnology or pharmaceutical industry.
• Demonstrated ability to deliver impactful data and effectively lead multiple projects from an in vivo perspective.
• Must have strong hands-on experience (leading from the bench) developing and working with oncology in vivo mouse models including xenografts (subcutaneous and disseminated models).
• Hands-on experience handling rodents (mice required, rats preferred) and with high proficiency in oral, intraperitoneal, and intravenous dosing. Must be comfortable and highly proficient working with different rodent strains including NSG mice, C57BL6 mice, SRG rats, etc.
• Ability to deliver in vivo pharmacology data packages for small molecule programs in rodents tumor models including dose-finding tolerability studies, PK/PD, and efficacy studies. Complex mouse model development experience is highly desirable.
• Experience in using molecular and cellular biology techniques such as immunoblotting platforms, flow cytometry, RT-PCR platforms, and MSD/ELISA assay development is required.
• Development and validation of in vivo PD assays such as qPCR, MSD, and ELISA for evaluating analytes of interest from in vivo samples from tumor, tissue, bone marrow, blood and urine samples for biomarker evaluation.
• Excellent communication, organizational, and listening skills are required.
• Familiarity with software programs including GraphPad Prism, Microsoft Office suite, and in vivo data capture systems. AI based strategies for in vivo related activities are highly encouraged.
• Strong interpersonal and collaboration skills, with evidence of delivery in a team-oriented, collaborative environment. Must be able to balance time at the bench, in the vivarium and project responsibilities.

Nice To Haves

• Prior experience in biotech or pharma.
• Expertise in multiple myeloma, lymphoma, or/and acute myelogenous leukemia biology and/or rodent models.
• Hands-on experience using small animal imaging modalities such as bioluminescence imaging (IVIS).
• Strong publication track record.
• Hands-on experience with spectral flow cytometry.
• Hands-on experience in assay development for complex systems (ex. in vivo samples, ex vivo 3D cultures, ex vivo co-culture etc.).

Responsibilities

• Develop, design, conduct and analyze in vivo experiments to assess the PK/PD/efficacy relationships and function of novel cancer therapeutics.
• Work collaboratively across multiple project teams and scientific disciplines to advance drug projects.
• Work with various software programs and databases, including AI platforms to capture all study data and data mining.
• Stay up to date with relevant scientific and technical expertise in cancer biology and pharmacology by actively reading the literature, attending relevant conferences.
• Independently provide data analysis, troubleshooting and interpretation.
• Manage timelines for study delivery.
• Proactively and clearly communicate within the in vivo team and the broader AZ organization.
• Bring genuine curiosity for in vivo oncology research.

Benefits

• Competitive remuneration and benefits apply
• Competitive Total Reward program including a market driven base salary, bonus and long-term incentive.
• Generous paid time off program
• Comprehensive benefits package
• Eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles.
• Qualified retirement programs
• Paid time off (i.e., vacation, holiday, and leaves)
• Health, dental, and vision coverage in accordance with the terms of the applicable plans.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree