Associate Scientist/Senior Associate Scientist, In Vivo Pharmacology– Study Coordinator

Manifold Bio•Boston, MA

18h•$106,000 - $123,000•Onsite

About The Position

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies. Position We are seeking an experienced and highly organized In Vivo Study Coordinator to own the end-to-end planning, coordination, and execution of our preclinical in vivo pharmacology programs. This is a senior, hands-on role at the intersection of scientific rigor and operational excellence — you will be the single point of accountability for study lifecycle management across multiple parallel programs, from initial study design through execution, collection, and delivery. The ideal candidate brings deep in vivo pharmacology expertise, strong cross-functional coordination instincts, and the ability to operate independently in a fast-moving, early-stage environment. You are as comfortable building a detailed study timeline as you are troubleshooting a dosing day in real time — and you know when to push back on unrealistic timelines and when to find creative solutions.

Requirements

Bachelor's or Master's degree in Biology, Pharmacology, Biomedical Science, or related field
5+ years of hands-on in vivo pharmacology experience in a biotech, pharma, or CRO environment
Demonstrated experience as a study director, study coordinator, or study lead — owning studies end-to-end with accountability for timelines and deliverables
Deep proficiency with in vivo techniques: IV, SC, IP, and PO dosing; submandibular and cardiac bleeds; necropsy; tissue collection and processing across a broad panel
Experience coordinating multiple concurrent studies across different programs and timelines
Strong organizational skills and attention to detail — you do not let things slip
Excellent cross-functional communication — comfortable working with scientists, RAs, vivarium staff, and leadership simultaneously
Self-motivated and capable of operating independently with minimal supervision
A genuine passion for science and for building something impactful

Nice To Haves

Experience with humanized or disease mouse models
Familiarity with NHP study coordination and CRO management
Experience with downstream bioanalytical assays — ELISA, MSD, qPCR, western blot, flow cytometry, IHC, IF
Familiarity with histology, tissue sectioning, and confocal imaging workflows
Experience with Benchling or similar LIMS platforms
Exposure to protein therapeutics and other modalities
Experience writing detailed study plans, SOPs, and IACUC protocol amendments
Comfortable with data analysis tools including GraphPad Prism and Microsoft Office

Responsibilities

Own end-to-end study coordination across multiple concurrent in vivo programs — from animal ordering and acclimation through dosing, bleeding, necropsy, tissue collection, and downstream handoff
Develop and maintain detailed study plans, timelines, and execution schedules — including who does what, when, and how, with clear accountability at every step
Serve as the primary point of contact between scientists, VIVO team members, vivarium staff, and external CROs — ensuring alignment on study design, timelines, and deliverables
Contribute to study design in collaboration with program leads — including dose selection, group sizes, timepoints, route of administration, and endpoint strategy
Perform and oversee hands-on in vivo procedures including dosing (IV, SC, IP, PO), bleeds, perfusion, necropsy, and tissue collection as needed
Write, review, and refine study protocols and SOPs; contribute to protocol amendments as studies evolve
Track and manage animal orders, reagent inventory, and study materials to ensure readiness ahead of each experiment
Identify bottlenecks and resource conflicts across the study portfolio and proactively surface solutions
Mentor and train junior VIVO team members on in vivo techniques and study execution best practices
Maintain accurate, organized records and data entry in Benchling and other platforms
Coordinate with external CROs and vendors on outsourced study components — review SOWs, monitor timelines, and ensure data quality