Principal Investigator (MD/DO)

ALLIANCE CLINICAL LLC • Pittsburgh, PA

1d • Onsite

About The Position

Alliance Clinical Network is seeking an Internal Medicine / Family Medicine / Specialist physician (MD/DO) with clinical research experience to help build a new clinical research site from the ground up in Pittsburgh, PA. The Principal Investigator will provide clinical and medical guidance as the site establishes itself and grows its research portfolio. This role offers the opportunity to make an impact without the demands of a traditional full-time clinical practice, providing a more predictable schedule and the chance to fully contribute time to clinical research. The position is ideal for a physician who enjoys medicine and clinical research and wants to remain clinically engaged.

Requirements

• MD or DO with a background in Internal Medicine, Family Medicine or a Specialist
• Active, unrestricted Pennsylvania medical license
• Prior clinical research experience in a Principal Investigator, Sub-Investigator, or other clinical research physician capacity is required
• Strong clinical judgment and commitment to participant safety
• Interest in clinical research and advancing medical innovation
• Comfort reviewing structured clinical data and study-specific medical information
• Strong communication, documentation, and confidentiality practices
• Familiarity with ICH-GCP and FDA clinical research regulations
• Board certification
• DEA registration, if required by applicable study protocols

Nice To Haves

• Opportunity to transition into the role from your current work; starting at approximately 10 hours per week and moving to full-time
• No overnight call & rare urgent escalations
• Predictable research visits and structured protocols
• Focused interactions with study participants rather than a traditional high-volume clinic
• A dedicated research team managing day-to-day study coordination
• Structured PI onboarding and mentorship
• Protocol-specific training
• Support from other experienced Principal Investigators
• Ongoing partnership with clinical operations, regulatory, and quality teams
• Established SOPs, templates, and documentation workflows
• Continued support throughout the life of your studies

Responsibilities

• Provide medical oversight and clinical leadership for assigned clinical trials, with patient safety and data quality at the center of your work.
• Serve as the study physician and provide medical oversight for assigned clinical trials.
• Protect the safety, rights, and well-being of research participants throughout the study.
• Review and confirm participant eligibility and provide medical oversight of screening outcomes.
• Review adverse events (AEs), serious adverse events (SAEs), and participant safety trends.
• Perform or oversee study-specific medical assessments, including medical histories, physical examinations, concomitant medications, and endpoint assessments.
• Provide clinical guidance and medical oversight to Sub-Investigators, Clinical Research Coordinators, RNs, and other site staff.
• Serve as a clinical resource for study-related medical questions and safety concerns.
• Collaborate with study sponsors, CROs, IRBs, and Alliance leadership throughout the life of each trial.
• Participate in Site Initiation Visits, monitoring visits, close-out activities, and other study meetings as needed.
• Review clinical data including laboratory results, ECGs, vital signs, and other study-specific assessments.
• Support timely safety reporting, medical documentation, and resolution of clinical data queries.
• Maintain compliance with study protocols, site SOPs, ICH-GCP, FDA regulations, and applicable Florida requirements.
• Contribute to a culture of quality, continuous improvement, and patient-centered research.

Benefits

• High-quality, patient-centered clinical research
• Meaningful role in bringing medical innovation to life
• Opportunity to build a new clinical research site from the ground up
• Provide clinical and medical guidance
• Shape the site's success
• Opportunity to make an impact without the demands of a traditional full-time clinical practice
• More predictable schedule
• Opportunity to fully contribute time to clinical research
• Stay engaged in cutting edge medicine
• Maintain meaningful clinical involvement without the high volume / low impact environment of a traditional practice
• Bring research opportunities to local patients
• Connect patients with clinical trials investigating new therapies and advancing the future of medicine
• Work with a team behind you
• Experienced clinical operations, regulatory, quality, and research staff provide infrastructure and support
• Establish yourself as a key physician leader within a growing clinical research network
• No overnight call & rare urgent escalations
• Focused interactions with study participants
• Dedicated research team managing day-to-day study coordination
• Structured PI onboarding and mentorship
• Protocol-specific training
• Support from other experienced Principal Investigators
• Ongoing partnership with clinical operations, regulatory, and quality teams
• Established SOPs, templates, and documentation workflows
• Continued support throughout the life of your studies

What This Job Offers

• Job Type: Full-time
• Career Level: Principal