Principal Investigator (MD/DO)

ALLIANCE CLINICAL LLC•Indianapolis, IN

1d•Onsite

About The Position

Alliance Clinical Network is seeking an Internal Medicine / Family Medicine / Specialist physician (MD/DO) with clinical research experience to establish and lead a new clinical research site in Indianapolis, IN. This role offers the opportunity to build a research site from the ground up, providing clinical and medical guidance, shaping the site's success, and making an impact without the demands of a traditional full-time clinical practice. It is ideal for a physician who enjoys medicine and clinical research, desires a more predictable schedule, and wants to dedicate their time to clinical research. The position involves providing medical oversight and clinical leadership for assigned clinical trials, ensuring patient safety and data quality. The Principal Investigator will serve as the study physician, protect participant rights and well-being, review eligibility and safety data, perform medical assessments, guide site staff, and collaborate with sponsors, CROs, IRBs, and Alliance leadership. Responsibilities also include participating in study visits, reviewing clinical data, supporting safety reporting, and maintaining compliance with regulations and protocols. The role emphasizes a culture of quality, continuous improvement, and patient-centered research.

Requirements

MD or DO with a background in Internal Medicine, Family Medicine or a Specialist
Active, unrestricted Indiana medical license
Prior clinical research experience in a Principal Investigator, Sub-Investigator, or other clinical research physician capacity is required
Strong clinical judgment and commitment to participant safety
Interest in clinical research and advancing medical innovation
Comfort reviewing structured clinical data and study-specific medical information
Strong communication, documentation, and confidentiality practices
Familiarity with ICH-GCP and FDA clinical research regulations
Board certification
DEA registration, if required by applicable study protocols

Responsibilities

Serve as the study physician and provide medical oversight for assigned clinical trials.
Protect the safety, rights, and well-being of research participants throughout the study.
Review and confirm participant eligibility and provide medical oversight of screening outcomes.
Review adverse events (AEs), serious adverse events (SAEs), and participant safety trends.
Perform or oversee study-specific medical assessments, including medical histories, physical examinations, concomitant medications, and endpoint assessments.
Provide clinical guidance and medical oversight to Sub-Investigators, Clinical Research Coordinators, RNs, and other site staff.
Serve as a clinical resource for study-related medical questions and safety concerns.
Collaborate with study sponsors, CROs, IRBs, and Alliance leadership throughout the life of each trial.
Participate in Site Initiation Visits, monitoring visits, close-out activities, and other study meetings as needed.
Review clinical data including laboratory results, ECGs, vital signs, and other study-specific assessments.
Support timely safety reporting, medical documentation, and resolution of clinical data queries.
Maintain compliance with study protocols, site SOPs, ICH-GCP, FDA regulations, and applicable Florida requirements.
Contribute to a culture of quality, continuous improvement, and patient-centered research.

Benefits

Opportunity to transition into the role from your current work; starting at approximately 10 hours per week and moving to full-time
No overnight call & rare urgent escalations
Predictable research visits and structured protocols
Focused interactions with study participants rather than a traditional high-volume clinic
A dedicated research team managing day-to-day study coordination
Structured PI onboarding and mentorship
Protocol-specific training
Support from other experienced Principal Investigators
Ongoing partnership with clinical operations, regulatory, and quality teams
Established SOPs, templates, and documentation workflows
Continued support throughout the life of your studies