Principal Investigator (MD/DO)

ALLIANCE CLINICAL LLC•Oklahoma City, OK

1d•Onsite

About The Position

Alliance Clinical Network is seeking an Internal Medicine / Family Medicine / Specialist physician (MD/DO) with clinical research experience to help build a new clinical research site from the ground up in Oklahoma City. As the Principal Investigator, you will provide clinical and medical guidance, shape the site’s success, and make an impact without the demands of a traditional full-time clinical practice. This role is ideal for a physician who enjoys medicine and clinical research, wants to remain clinically engaged with a more predictable schedule, and desires to fully contribute their time to clinical research. The opportunity offers the chance to build a new site, have a meaningful voice in participant experience, stay engaged in cutting-edge medicine, bring research opportunities to local patients, work with a supportive team, and grow within the Alliance network.

Requirements

MD or DO with a background in Internal Medicine, Family Medicine or a Specialist
Active, unrestricted Oklahoma medical license
Prior clinical research experience in a Principal Investigator, Sub-Investigator, or other clinical research physician capacity is required
Strong clinical judgment and commitment to participant safety
Interest in clinical research and advancing medical innovation
Comfort reviewing structured clinical data and study-specific medical information
Strong communication, documentation, and confidentiality practices
Familiarity with ICH-GCP and FDA clinical research regulations
Board certification
DEA registration, if required by applicable study protocols

Responsibilities

Provide medical oversight and clinical leadership for assigned clinical trials, with patient safety and data quality at the center of your work.
Serve as the study physician and provide medical oversight for assigned clinical trials.
Protect the safety, rights, and well-being of research participants throughout the study.
Review and confirm participant eligibility and provide medical oversight of screening outcomes.
Review adverse events (AEs), serious adverse events (SAEs), and participant safety trends.
Perform or oversee study-specific medical assessments, including medical histories, physical examinations, concomitant medications, and endpoint assessments.
Provide clinical guidance and medical oversight to Sub-Investigators, Clinical Research Coordinators, RNs, and other site staff.
Serve as a clinical resource for study-related medical questions and safety concerns.
Collaborate with study sponsors, CROs, IRBs, and Alliance leadership throughout the life of each trial.
Participate in Site Initiation Visits, monitoring visits, close-out activities, and other study meetings as needed.
Review clinical data including laboratory results, ECGs, vital signs, and other study-specific assessments.
Support timely safety reporting, medical documentation, and resolution of clinical data queries.
Maintain compliance with study protocols, site SOPs, ICH-GCP, FDA regulations, and applicable Florida requirements.
Contribute to a culture of quality, continuous improvement, and patient-centered research.

Benefits

Opportunity to transition into the role from your current work; starting at approximately 10 hours per week and moving to full-time
No overnight call & rare urgent escalations
Predictable research visits and structured protocols
Focused interactions with study participants rather than a traditional high-volume clinic
A dedicated research team managing day-to-day study coordination
Structured PI onboarding and mentorship
Protocol-specific training
Support from other experienced Principal Investigators
Ongoing partnership with clinical operations, regulatory, and quality teams
Established SOPs, templates, and documentation workflows
Continued support throughout the life of your studies