Principal Investigator (MD/DO)
About The Position
Alliance Clinical Network is seeking an Internal Medicine / Family Medicine / Specialist physician (MD/DO) with clinical research experience to establish and lead a new clinical research site in Kansas City, MO. This role offers the opportunity to provide clinical and medical guidance, shape the site's success, and make a significant impact in advancing medical innovation through patient-centered clinical research. The position allows for meaningful clinical engagement with a more predictable schedule than traditional practice, focusing on clinical research and contributing to the future of medicine by connecting local patients with clinical trials investigating new therapies. The site will be supported by experienced clinical operations, regulatory, quality, and research staff.
Requirements
- MD or DO with a background in Internal Medicine, Family Medicine or a Specialist
- Active, unrestricted Missouri medical license
- Prior clinical research experience in a Principal Investigator, Sub-Investigator, or other clinical research physician capacity is required
- Strong clinical judgment and commitment to participant safety
- Interest in clinical research and advancing medical innovation
- Comfort reviewing structured clinical data and study-specific medical information
- Strong communication, documentation, and confidentiality practices
- Familiarity with ICH-GCP and FDA clinical research regulations
- Board certification
- DEA registration, if required by applicable study protocols
Responsibilities
- Serve as the study physician and provide medical oversight for assigned clinical trials.
- Protect the safety, rights, and well-being of research participants throughout the study.
- Review and confirm participant eligibility and provide medical oversight of screening outcomes.
- Review adverse events (AEs), serious adverse events (SAEs), and participant safety trends.
- Perform or oversee study-specific medical assessments, including medical histories, physical examinations, concomitant medications, and endpoint assessments.
- Provide clinical guidance and medical oversight to Sub-Investigators, Clinical Research Coordinators, RNs, and other site staff.
- Serve as a clinical resource for study-related medical questions and safety concerns.
- Collaborate with study sponsors, CROs, IRBs, and Alliance leadership throughout the life of each trial.
- Participate in Site Initiation Visits, monitoring visits, close-out activities, and other study meetings as needed.
- Review clinical data including laboratory results, ECGs, vital signs, and other study-specific assessments.
- Support timely safety reporting, medical documentation, and resolution of clinical data queries.
- Maintain compliance with study protocols, site SOPs, ICH-GCP, FDA regulations, and applicable Florida requirements.
- Contribute to a culture of quality, continuous improvement, and patient-centered research.
Benefits
- Opportunity to transition into the role from your current work; starting at approximately 10 hours per week and moving to full-time
- No overnight call & rare urgent escalations
- Predictable research visits and structured protocols
- Focused interactions with study participants rather than a traditional high-volume clinic
- A dedicated research team managing day-to-day study coordination
- Structured PI onboarding and mentorship
- Protocol-specific training
- Support from other experienced Principal Investigators
- Ongoing partnership with clinical operations, regulatory, and quality teams
- Established SOPs, templates, and documentation workflows
- Continued support throughout the life of your studies
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What This Job Offers
Job Type
Full-time
Career Level
Principal
