Principal Investigator (MD/DO)
About The Position
Alliance Clinical Network is seeking an Internal Medicine / Family Medicine / Specialist physician (MD/DO) with clinical research experience to establish and lead a new clinical research site in Columbus, OH. This role offers the opportunity to build a research site from the ground up, providing clinical and medical guidance, and shaping the site's success. It is ideal for a physician who enjoys medicine and clinical research, desires a more predictable schedule than traditional practice, and wants to fully contribute their time to clinical research. The position involves providing medical oversight and clinical leadership for assigned clinical trials, with a focus on patient safety and data quality. The Principal Investigator will serve as the study physician, protect participant rights and well-being, review eligibility and safety data, perform medical assessments, and guide site staff. Collaboration with sponsors, CROs, IRBs, and Alliance leadership is expected, along with participation in study-related visits and meetings. The role also includes reviewing clinical data, supporting safety reporting, ensuring compliance with regulations, and fostering a culture of quality and patient-centered research.
Requirements
- MD or DO with a background in Internal Medicine, Family Medicine or a Specialist
- Active, unrestricted Ohio medical license
- Prior clinical research experience in a Principal Investigator, Sub-Investigator, or other clinical research physician capacity is required
- Strong clinical judgment and commitment to participant safety
- Interest in clinical research and advancing medical innovation
- Comfort reviewing structured clinical data and study-specific medical information
- Strong communication, documentation, and confidentiality practices
- Familiarity with ICH-GCP and FDA clinical research regulations
- Board certification
- DEA registration, if required by applicable study protocols
Responsibilities
- Serve as the study physician and provide medical oversight for assigned clinical trials.
- Protect the safety, rights, and well-being of research participants throughout the study.
- Review and confirm participant eligibility and provide medical oversight of screening outcomes.
- Review adverse events (AEs), serious adverse events (SAEs), and participant safety trends.
- Perform or oversee study-specific medical assessments, including medical histories, physical examinations, concomitant medications, and endpoint assessments.
- Provide clinical guidance and medical oversight to Sub-Investigators, Clinical Research Coordinators, RNs, and other site staff.
- Serve as a clinical resource for study-related medical questions and safety concerns.
- Collaborate with study sponsors, CROs, IRBs, and Alliance leadership throughout the life of each trial.
- Participate in Site Initiation Visits, monitoring visits, close-out activities, and other study meetings as needed.
- Review clinical data including laboratory results, ECGs, vital signs, and other study-specific assessments.
- Support timely safety reporting, medical documentation, and resolution of clinical data queries.
- Maintain compliance with study protocols, site SOPs, ICH-GCP, FDA regulations, and applicable Florida requirements.
- Contribute to a culture of quality, continuous improvement, and patient-centered research.
Benefits
- Opportunity to transition into the role from your current work; starting at approximately 10 hours per week and moving to full-time
- No overnight call & rare urgent escalations
- Predictable research visits and structured protocols
- Focused interactions with study participants rather than a traditional high-volume clinic
- A dedicated research team managing day-to-day study coordination
- Structured PI onboarding and mentorship
- Protocol-specific training
- Support from other experienced Principal Investigators
- Ongoing partnership with clinical operations, regulatory, and quality teams
- Established SOPs, templates, and documentation workflows
- Continued support throughout the life of your studies
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What This Job Offers
Job Type
Full-time
Career Level
Senior
