Director, Therapeutic Genome Editing Specificity

We are seeking a Director, Therapeutic Genome Editing with scientific leadership experience in molecular biology and genome engineering to lead our off-target characterization efforts. This role will involve providing strategic leadership in developing and operationalizing genome-wide off-target characterization methods, as well as leading a team of talented Scientists and Research Associates. The Director will play a pivotal role in assessing the impact on genome integrity of lead therapeutic candidates and delivering pivotal genome editing specificity datasets to support therapeutic candidate development.

• Provide strategic leadership to develop and operationalize genome-wide off-target characterization methods
• Motivate and lead a team of talented Scientists and Research Associates
• Directly contribute to the selection and design of therapeutic candidates
• Work collaboratively with key stakeholders to deliver pivotal genome editing specificity datasets
• Partner with internal bioinformatics and data science team for high throughput method development and data analysis pipelines
• Prepare accurate and timely data summaries and contribute to technical study reports, papers, and patent applications
• Participate in regulatory interaction meetings and provide strategic communication of off-target characterization results
• Have a Ph.D. in STEM-related discipline and at least eight (8) years of biopharma industry experience
• Have at least five (5) years of highly relevant experience leading the development of genome editing specificity assays
• Have substantial expertise in DNA repair pathways, mechanisms of cellular transformation, and leveraging functional genomics datasets
• Have experience working with large datasets, including UK Biobank, Finngen, and resources like GnomAD, Exome variant server, 1000 Genomes, etc.
• Have a track record of successfully operationalizing genome editing characterization workflows and developing study reports supporting regulatory filings
• Have exceptional quantitative skills and experience analyzing large experimental data in partnership with computational biologists
• Be extremely organized and able to efficiently manage time and workflows
• Have direct supervisory experience leading teams of Scientists and Research Associates
• Have outstanding communication, collaboration, and team leadership skills.

• Ph.D. in STEM-related discipline and at least eight (8) years of biopharma industry experience
• At least five (5) years of highly relevant experience leading the development of genome editing specificity assays, including on/off target analysis
• Substantial expertise in DNA repair pathways, mechanisms of cellular transformation, and leveraging functional genomics datasets to interpret off-target assay output
• Experience working with large datasets, including UK Biobank, Finngen, and resources, i.e., GnomAD, Exome variant server, 1000 Genomes, etc.
• Track record of successfully operationalizing genome editing characterization workflows and developing study reports supporting regulatory filings
• Exceptional quantitative skills, including experience analyzing large experimental data in partnership with computational biologists to draw statistically significant conclusions
• Extremely organized and able to efficiently manage your time and workflows, including skillfully prioritizing both long-term projects and the day-to-day responsibilities of your team
• Direct supervisory experience leading teams of Scientists and Research Associates with a track record of recruiting, mentoring, and developing talent
• Outstanding communication, collaboration, and team leadership skills.

• Competitive compensation including a market-benchmarked salary
• Annual target bonus
• Equity in an early-stage startup
• Comprehensive benefits plan
• 401(k) matching
• Retirement safe harbor plan
• Weekly employee happy hour and events
• Catered lunches
• Endless snacks
• Open, collegial, and friendly work environment
• Opportunities for long-term career development
• Equal-opportunity employer
• Diversity and inclusion valued
• No discrimination based on race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law.