Associate Director Global Health Economic and Outcomes Research Scientist

Denali Therapeutics•South San Francisco, CA

6d•$139,000 - $180,000

About The Position

The Associate Director Global Health Economic and Outcomes Research Scientist develops and communicates evidence establishing product value, including health economic evidence and real-world evidence (RWE), and disseminates that evidence to support healthcare decision-making. The role is global in scope, with primary initial responsibility for developing and disseminating evidence for US stakeholders and a supportive role on global evidence deliverables. The successful candidate applies methodological expertise across health economics, outcomes research, and RWE, and executes work end to end—from strategy development through tactical execution and publication. The position requires cross-functional collaboration and coordination with Clinical Development, Medical Affairs, Biometrics, Marketing, US and International Market Access, field teams, and other functions to maintain consistent value evidence across markets. The role also manages HEOR vendors and consultants.

Requirements

Advanced graduate degree in a relevant discipline such as health services research, health economics, epidemiology, or public health; PhD preferred.
Typically, at least 12 years of related experience with a bachelor's degree, 10 years with a master's degree, or 7 years with a PhD; equivalent experience is also accepted.
Knowledge of US and global healthcare systems, US payer and global HTA evidence requirements, and clinical development sufficient to define product value propositions, identify evidence gaps, and formulate evidence-generation and communication strategies.
Demonstrated research capability in HEOR study design, analysis, and interpretation, with accountability for scientific and technical rigor of HEOR deliverables.
Experience leading economic modeling, evidence synthesis including systematic review and indirect treatment comparison, and observational study design using US real-world data sources.
Experience developing AMCP dossiers and healthcare economic information for US population-based decision makers, including familiarity with the regulatory and compliance framework governing communication of that information.
Proven record of end-to-end project execution, from concept development through publication.
Ability to execute HEOR projects independently with minimal guidance.
Excellent communication, presentation, collaboration, and influencing skills across internal and external stakeholders in a multicultural environment.

Nice To Haves

Experience leading HEOR strategy development and execution in support of a product launch.
Experience in outcomes research in rare disease and/or neurodegenerative therapeutic areas.
Familiarity with ex-US HTA evidence requirements and experience contributing to global value dossier development.

Responsibilities

Develop and execute HEOR strategic plans for assigned programs, with primary accountability for US evidence needs and alignment with commercial, clinical, medical, and market access plans.
Design and execute HEOR studies, including economic modeling, real-world evidence, clinical outcomes assessment, indirect treatment comparisons, and systematic literature reviews.
Design and oversee real-world evidence studies using US claims, electronic health record, registry, and primary data sources, including source selection, feasibility assessment, and data access and governance.
Develop economic models and healthcare economic information (HCEI), and train field teams to communicate effectively and compliantly with population-based decision makers.
Provide input into clinical development program design to support inclusion of design elements and endpoints relevant to payers, clinicians, and patients.
Lead AMCP dossier development and synthesize health economic and outcomes evidence contributing to global value dossier development.
Lead the HEOR dissemination strategy in alignment with the overall product communication strategy, including timely publication of abstracts and manuscripts and presentation at scientific congresses.
Support selected ex-US evidence deliverables and coordinate US and ex-US evidence in line with the global evidence strategy.
Collaborate cross-functionally with market access, medical affairs, biometrics, commercial, operations, and clinical development to integrate HEOR plans into the broader strategic framework.
Manage HEOR vendors and consultants, ensuring deliverables meet objectives, quality standards, and timelines.