Associate Director, Outcomes Research

Tempus AI•Remote - Illinois, IL

2d•$150,000 - $210,000

About The Position

The Associate Director, Outcomes Research will lead high-impact outcomes research for Tempus’s biopharma partners in a high-visibility, client-facing role within the Data Business. The position combines traditional outcomes research with data science, developing and validating novel epidemiological methods to use Tempus’s multimodal datasets and generate regulatory-grade insights that support drug development and patient outcomes. The role oversees retrospective database analyses, advises biopharma clients on innovative study designs, and develops methods for real-world evidence, including external control arms, causal inference in high-dimensional data, and integration of longitudinal clinical data with molecular and genomic signatures. It also drives scientific dissemination through publications and conference presentations, collaborates with Data Science, Biostatistics, and Product teams to scale successful methods, and ensures research meets regulatory and ethical standards. The Associate Director manages a small team of outcomes research scientists, providing project guidance and supporting their career development.

Requirements

PhD (preferred), PharmD, or master’s degree in Epidemiology, Biostatistics, Health Economics, or a related quantitative field.
At least 7 years of experience in HEOR/RWE.
At least 3 years of experience in a leadership capacity.
Deep expertise in oncology.
Proven track record developing or implementing advanced analytical methods, such as target trial emulation, propensity score applications in complex cohorts, causal inference, or machine-learning-augmented epidemiology.
Advanced skills in R or SAS.
Experience working with real-world data such as EHR, claims, and/or genomic data.
Exceptional ability to explain complex methodological challenges to biopharma executives and turn them into a clear strategic roadmap.
Demonstrated experience managing junior scientists and leading cross-functional squads in a fast-paced, high-growth environment.
Creative problem-solving ability.

Responsibilities

Oversee end-to-end execution of retrospective database analyses and act as the primary architect for study protocols.
Advise biopharma clients as a subject matter expert, including on innovative and first-in-kind study designs.
Contribute to the scientific community through publications and presentations at conferences such as ISPOR, ISPE, and ASCO.
Partner with Key Account Directors and Business Development to identify opportunities where novel methods can address client problems, such as rare disease characterization and complex biomarker validation.
Lead development of novel real-world evidence methods, including external control arms, causal inference in high-dimensional data, and integration of longitudinal clinical data with molecular and genomic signatures.
Drive the strategy and roadmap for scientific dissemination, including authoring and publishing peer-reviewed manuscripts, abstracts, and conference presentations.
Partner with Data Science, Biostatistics, and Product teams to productize successful methods and make them scalable across the Tempus ecosystem.
Ensure research meets regulatory and ethical standards, including GEP and HIPAA, and deliver high-quality results on industry timelines.
Manage a small team of outcomes research scientists, providing hands-on analytical guidance and supporting career development and growth.
Lead cross-functional squads and provide scientific and methodological leadership.