Principal Research Associate, Mass Spectrometry
Foghorn Therapeutics • Watertown, MA41d
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Principal Research Associate, Mass Spectrometry
Foghorn Therapeutics•Watertown, MA
About The Position
This role will support drug discovery efforts through research‑driven, MS–based analytical method development and deep scientific problem‑solving. It will contribute to advancing discovery programs through hands-on operation of instrumentation, development and execution of analytical workflows, and close collaboration with cross-functional scientists across research teams.
Requirements
- Bachelor’s or Master’s degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field.
- 3+ years of relevant laboratory experience in mass spectrometry, biochemistry, or analytical chemistry in a drug discovery, pharmaceutical, or biotechnology setting.
- Experience operating LC-MS, LC-MS/MS, or related analytical instrumentation, with a strong interest in hands-on instrument operation, maintenance, and troubleshooting.
- Demonstrated experience in research‑focused experimental work, such as assay development, method refinement, or troubleshooting complex datasets, beyond analytical testing.
Nice To Haves
- Experience developing and optimizing LC‑MS analytical methods, including innovating new research assays, adapting techniques to novel targets, or working through complex, non‑routine analytical challenges.
- Familiarity with intact MS, proteomics, or related mass spectrometry workflows.
- Experience with software tools for MS data processing and analysis.
Responsibilities
- Perform mass spectrometry–based analyses (e.g., proteomics, intact MS) to characterize small molecules, protein interactions, and other targets relevant to drug discovery programs.
- Operate, maintain, and troubleshoot analytical instrumentation, including LC-MS and related platforms.
- Develop, optimize, and execute analytical methods and exploratory assays, to support compound characterization, screening activities, and project workflows.
- Analyze and interpret experimental data, prepare summaries, and communicate results to cross-functional project teams.
- Collaborate with scientists across chemistry, biology, and pharmacology to advance discovery programs and provide mass spectrometry expertise.
- Contribute to experimental planning, documentation, reporting, and ownership of analytical workflows supporting research activities.
Benefits
- Highly competitive and inclusive medical, dental and vision coverage options
- FSA and HSA for medical expenses and dependent care expenses
- Free premium access to fitness, nutrition, and mindfulness classes
- Unlimited paid time off policy
- Discretionary winter shut down
- Generous Paid Leave offerings, including 12 weeks of 100% paid parental leave
- Paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
- Free parking or subsidized commuter passes
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
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