VP, Disease Business Unit General Manager, US

Vertex Inc.•Boston, MA

15d•$368,000 - $552,000•Onsite

About The Position

Vertex is seeking a seasoned commercial executive to lead a fully integrated U.S. Business Unit and own end-to-end business performance for a designated portfolio. The role is accountable for results delivery, performance management, budgets, and strategic priorities, leading commercial execution through cross-functional alignment to sustain market leadership and prepare for future innovation. The VP U.S. General Manager serves as the enterprise steward of Vertex’s designated U.S. therapeutic area franchise, balancing near-term performance with long-term sustainability in a highly penetrated, mature market. The position leads an established commercial organization, with direct reports across Sales and Marketing, and is responsible for launch execution, lifecycle management, revenue forecasting, expense management, resource allocation, leadership development, and ethical, compliant operations. The role works closely with functions across the company and with disease communities, advocacy organizations, treatment centers, and senior healthcare stakeholders. Vertex encourages continuous learning and thoughtful adoption of advances in AI, technology, automation, and industry trends to improve decision-making, innovation, efficiency, and patient outcomes. This is an on-site designated role requiring five days per week on-site, with ad hoc flexibility. The base salary range is $368,000–$552,000. The role is eligible for an annual bonus and annual equity awards. Vertex describes its total rewards as including medical, dental, and vision benefits; generous paid time off, including a week-long summer and winter company shutdown; educational assistance programs including student loan repayment; a commuting subsidy; matching charitable donations; and a 401(k).

Requirements

Typically 15+ years of pharmaceutical or biotech experience, with deep commercial leadership exposure.
At least 8–10 years of senior people leadership experience, including responsibility for large, matrixed organizations.
Demonstrated success leading large, in-market franchises with sustained performance over time.
Proven enterprise-level commercial leadership and strong strategic, financial, and operational acumen.
Ability to lead through scale and complexity while balancing performance delivery with long-term franchise stewardship.
Exceptional executive communication skills and ability to influence the EC, Board, and external stakeholders.
Strong track record of building leaders and developing future general managers.
Deep experience operating in cross-functional, highly regulated environments.
Demonstrated ability to manage significant budgets and complex trade-offs.
Uncompromising commitment to ethics, compliance, and Vertex’s values and reputation.

Nice To Haves

Experience in portfolio and lifecycle management.
Experience operating effectively within highly visible, enterprise-critical franchises.
Experience engaging externally with advocacy groups, policymakers, and senior healthcare stakeholders.

Responsibilities

Own full P&L responsibility for the designated U.S. Business Unit and deliver revenue, profitability, and long-range plan commitments.
Lead an established commercial organization, with direct reports across Sales and Marketing and opportunities for future builds.
Drive cross-functional leadership and decision-making across Market Access, Patient Services, Analytics, Commercial Operations, Medical Affairs, R&D, Manufacturing, Legal, Regulatory, Government Affairs, and Patient Advocacy.
Ensure excellence in launch execution for future indication expansions and lifecycle management.
Develop and maintain a high-performing leadership bench with strong succession planning.
Serve as enterprise steward of Vertex’s designated U.S. therapeutic area franchise, balancing near-term performance with long-term sustainability.
Lead the organization through the dynamics of a highly penetrated, mature market.
Partner with Medical Affairs and Patient Services on patient-centric engagement models reflecting lifelong treatment journeys.
Maintain trusted relationships with disease communities, including advocacy organizations and treatment centers.
Own the U.S. revenue forecast, expense management, and resource allocation in collaboration with Business Unit Leadership.
Champion operational rigor, continuous improvement, and ethical leadership, ensuring compliance with company policies and regulatory standards.

Benefits

Annual bonus eligibility.
Annual equity awards.
Medical insurance.
Dental insurance.
Vision insurance.
Generous paid time off, including a week-long company shutdown in the summer and winter.
Educational assistance programs, including student loan repayment.
Commuting subsidy.
Matching charitable donations.
401(k).