VP, Disease Business Unit General Manager, US
About The Position
Vertex is seeking a seasoned commercial executive to serve as U.S. General Manager for a designated Disease Business Unit. The VP is accountable for end-to-end business performance, including results delivery, performance management, budget, and strategic priorities. The role leads a fully integrated U.S. Business Unit, aligning cross-functional teams to sustain market leadership while preparing for future innovation. The position owns the business unit’s P&L, U.S. revenue forecast, expense management, and resource allocation. It leads an established commercial organization, with direct reports across Sales and Marketing, and stewards Vertex’s designated therapeutic area franchise in the United States. The VP balances near-term performance with long-term sustainability in a highly penetrated, mature market, while maintaining launch execution and lifecycle management excellence. The role is on-site five days per week, with ad hoc flexibility. It is eligible for an annual bonus and annual equity awards. Vertex describes its total rewards as including medical, dental, and vision benefits, generous paid time off, a week-long company shutdown in summer and winter, educational assistance including student loan repayment, a commuting subsidy, matching charitable donations, and a 401(k).
Requirements
- Typically 15 or more years of pharmaceutical or biotech experience, with deep commercial leadership exposure.
- At least 8–10 years of senior people leadership experience, including responsibility for large, matrixed organizations.
- Demonstrated success leading large, in-market franchises with sustained performance over time.
- Proven enterprise-level commercial leadership with strong strategic, financial, and operational acumen.
- Ability to lead through scale and complexity while balancing performance delivery with long-term franchise stewardship.
- Exceptional executive communication skills and ability to influence the EC, Board, and external stakeholders.
- Strong track record of building leaders and developing future general managers.
- Deep experience operating in cross-functional, highly regulated environments.
- Demonstrated ability to manage significant budgets and complex trade-offs.
- Uncompromising commitment to ethics, compliance, and Vertex’s values and reputation.
Nice To Haves
- Experience in portfolio and lifecycle management.
- Experience operating effectively within highly visible, enterprise-critical franchises.
- Experience engaging externally with advocacy groups, policymakers, and senior healthcare stakeholders.
Responsibilities
- Own full P&L responsibility for the U.S. designated Business Unit and deliver revenue, profitability, and long-range plan commitments.
- Lead an established commercial organization, with opportunities for future builds and direct reports across Sales and Marketing.
- Drive cross-functional leadership and decision-making across Market Access, Patient Services, Analytics, Commercial Operations, Medical Affairs, R&D, Manufacturing, Legal, Regulatory, Government Affairs, and Patient Advocacy.
- Ensure excellence in launch execution for future indication expansions and in lifecycle management.
- Develop and maintain a high-performing leadership bench with strong succession planning.
- Serve as enterprise steward of Vertex’s designated U.S. therapeutic area franchise, balancing near-term performance with long-term sustainability.
- Lead the organization through the dynamics of a highly penetrated, mature market.
- Partner with Medical Affairs and Patient Services to ensure patient-centric engagement models reflect lifelong treatment journeys.
- Maintain trusted relationships with disease communities, including advocacy organizations and treatment centers.
- Own the U.S. revenue forecast, expense management, and resource allocation in collaboration with the Business Unit Leadership.
- Champion operational rigor, continuous improvement, and ethical leadership, ensuring compliance with company policies and regulatory standards.
Benefits
- Annual bonus eligibility.
- Annual equity awards.
- Medical benefits.
- Dental benefits.
- Vision benefits.
- Generous paid time off, including a week-long company shutdown in summer and winter.
- Educational assistance programs, including student loan repayment.
- Commuting subsidy.
- Matching charitable donations.
- 401(k).
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Executive
Education Level
No Education Listed
