Sr. Executive Assistant and Office Operations Manager

Oruka Therapeutics•Menlo Park, CA

2d•Hybrid

About The Position

Oruka Therapeutics (Nasdaq: ORKA) is developing novel biologics designed to set a new standard for the treatment of chronic skin diseases. Oruka’s mission is to offer patients suffering from chronic skin diseases like plaque psoriasis the greatest possible freedom from their condition by achieving high rates of complete disease clearance with dosing as infrequently as once or twice per year. Oruka is advancing a proprietary portfolio of potentially best-in-class antibodies that were engineered by Paragon Therapeutics and target the core mechanisms underlying plaque psoriasis and other dermatologic and inflammatory diseases. As we build our core team, we're seeking top talent in different functional areas who are not just looking for a job, but an opportunity to be part of something bigger. Someone who is passionate about making a difference and eager to contribute to establishing an engaged, inclusive, and positive company culture. The Senior Executive Assistant & Office Operations Manager plays a critical role in supporting the CEO and selected members of the Leadership Team, enabling them to focus on strategic priorities and company growth. This position is ideal for a highly organized, proactive professional who thrives in a fast-paced environment, enjoys managing logistics, and is energized by creating seamless operations and engaging company events. The role requires exceptional professionalism, adaptability, and the ability to handle sensitive information with the utmost discretion.

Requirements

Bachelor’s degree or equivalent relevant experience
5+ years of supporting C-level executives, including CEO, preferably within a startup, biotech, or life sciences environment
Exceptional organizational and prioritization skills, with the ability to manage multiple competing demands effectively
Strong judgment and proactive mindset, with the ability to anticipate needs and operate independently
Demonstrated adaptability and execution in a dynamic, fast-changing environment
Excellent written and verbal communication skills, with strong attention to detail
High level of integrity and discretion in handling confidential information
Advanced proficiency in Microsoft Office (Outlook, PowerPoint, Excel, Word)
Resourceful, solutions-oriented approach with a focus on continuous improvement
Passion for fostering workplace culture and enthusiasm for planning and executing events

Responsibilities

Manage calendars, coordinate domestic and international travel, process expense reports, and maintain critical documents with a high level of accuracy and attention to detail.
Lead the planning and execution of offsite meetings and company-wide events, including venue selection, logistics coordination, and agenda development to ensure successful, high-impact experiences.
Serve as a key liaison between the executive team and internal/external stakeholders, ensuring clear, timely, and professional communication.
Champion a positive and inclusive workplace culture by organizing team-building activities and initiatives that enhance employee engagement and morale.
Oversee daily office operations to ensure a smooth, efficient, and well-functioning environment.
Manage office supplies, kitchen inventory, and vendor relationships.
Address employee requests and resolve minor operational issues in a timely manner.
Maintain an organized and productive workspace that supports overall team effectiveness.