Sr Director, GMASE Portfolio Execution- RIRU

GSK

1d•$189,750 - $316,250

About The Position

The Sr Director of Global Monitoring & Site Engagement (GMASE) Portfolio Execution for RIRU is the single accountable leader for therapeutic-area execution within GMASE. The role translates R&D and therapeutic strategy into predictable, high-quality clinical delivery at scale, owning how GMASE plans, deploys, and optimizes resources, site engagement, monitoring approaches, and risk management across the therapeutic-area portfolio. It is accountable for execution, not for setting GSK therapeutic strategy or scientific direction. Working within the DevOps model, the role partners with Disease Area Leaders (DALs), therapeutic-area leadership, and DevOps counterparts to turn strategic intent into measurable improvements in velocity, quality, predictability, expertise, and productivity. It leads Global Program Leads (GPLs) and coordinates with Planning & Strategic Feasibility, GCSD, DS&M, Clinical Science, Regulatory, and external CRO partners to put the DevOps operating model into practice and support continuous, AI-enabled evidence generation. As a member of the GMASE Leadership Team, the role chairs therapeutic-area portfolio governance forums and provides portfolio-level insight and recommendations. The position requires at least 10 years of pharmaceutical R&D or related industry experience and extensive clinical-operations leadership experience in the relevant therapeutic area.

Requirements

Bachelor’s degree in life sciences, healthcare, business, or a related field, or equivalent experience.
At least 10 years of pharmaceutical R&D or related industry experience.
At least 8 years of leadership experience in clinical operations within the relevant therapeutic area.
Deep therapeutic-area expertise and understanding of Respiratory/Immunology strategy, data, operational needs, and commercial positioning.
Experience owning end-to-end execution outcomes at portfolio or therapeutic-area level, including delivery trade-offs, risk resolution, and performance.
Skills listed: Agile Thinking, Business Acumen, Clinical Development, Clinical Trial Designs, Communication, Creativity, Decision Making, Fostering Collaboration, Good Clinical Practice (GCP), Influencing Without Authority, People Management, Pharmaceutical Industry, Project Management, and Study Design.

Nice To Haves

Advanced degree (Master’s, PhD, PharmD, or MD) in a relevant discipline.
Experience with real-world evidence, health economics and outcomes research, or epidemiology.
Demonstrated ability to lead cross-functional teams, resolve complex issues, and drive study and portfolio performance.
Strong global stakeholder-management experience across GCSD, DS&M, Clinical Science, Regulatory, and country organizations.
Proven experience coaching and developing operational leaders.
Day-to-day fluency in using AI to accelerate trial timelines, improve data quality and evidence assurance, and reduce manual tasks.
Knowledge of Risk Based Quality Management.
Experience leading global portfolios or cross-region evidence programs.
Strong data fluency, including experience using dashboards and performance metrics to drive decisions.
Experience with vendor oversight and partnerships with CROs, academic networks, or external investigators.
Demonstrated success delivering process improvements or digital-enabled transformation in evidence generation.

Responsibilities

Own GMASE therapeutic-area execution across programs, studies, countries, and partners, aligned with DevOps principles and continuous, AI-enabled evidence generation.
Provide GMASE execution and delivery-feasibility input to Disease Area Strategy Plans and represent GMASE in therapeutic-area execution discussions, trade-offs, and delivery commitments with Disease Area Leaders and other stakeholders.
Align GMASE therapeutic-area execution with Planning & Strategic Feasibility, translating portfolio priorities, commercial positioning, feasibility insights, and delivery strategies into executable, scalable plans.
Oversee therapeutic-area portfolio performance by setting expectations, reviewing execution signals and evidence-assurance data, identifying systemic risks and constraints, and driving resolution through escalation and cross-functional decision-making.
Provide senior leadership and talent stewardship for Global Program Leads, including setting execution standards, strengthening decision quality, building leadership capability, and holding leaders accountable for performance; the role may include direct line management of GPLs.
Define and oversee therapeutic-area site engagement and relationship strategies, including site tiering aligned with enterprise priorities, to focus effort where it most improves velocity, quality, and predictability.
Own execution governance for outsourced delivery in the therapeutic area, set expectations with CRO partners, oversee performance, and resolve delivery issues and escalations.
Establish effective cross-functional execution governance, connecting GPLs and study teams with decision-makers across GCSD, DS&M, Clinical Science, Regulatory, and other partners to remove systemic barriers and prevent fragmented delivery.
As a GMASE Leadership Team member, chair therapeutic-area portfolio governance forums, including monthly reviews with Country Heads and functional partners, to drive performance transparency, resource alignment, and execution readiness; contribute therapeutic-area insight and recommendations to the Leadership Team.
Maximize use of AI-enabled tools and workflows across therapeutic-area execution and monitoring to accelerate trial timelines, reduce costs and manual tasks, and continuously optimize resource deployment and monitoring approaches based on utilization and delivery needs.