Sr. Associate Scientist - Oligonucleotide Chemistry

EMD Serono Research & Development Institute•Billerica, MA

2d•Onsite

About The Position

EMD Serono in Billerica, MA is seeking a Sr. Associate Scientist – Oligonucleotide Chemistry to add to their Oligonucleotide Therapeutics Group (DDTech). This role is part of the Healthcare sector, focused on helping create, improve, and prolong lives through the development of medicines, intelligent devices, and innovative technologies in therapeutic areas such as Oncology, Neurology, and Fertility. The company fosters a diverse, inclusive, and flexible working culture with opportunities for personal development and career advancement.

Requirements

Bachelor’s Degree in Chemical Engineering, Chemistry, Biochemistry or other Engineering or Life Science discipline AND 2+ years of experience in oligonucleotide field
OR Master’s Degree Chemical Engineering, Chemistry, Biochemistry or other Engineering or Life Science discipline

Nice To Haves

Good understanding of Oligonucleotide chemistry
Experience with a wide range of Oligo purification/analytical techniques, especially HPLC and/or HPLC-MS
Experience in performing desalting by using gel filtration or membrane filtration techniques
High degrees of flexibility and motivation in a fast-paced work environment

Responsibilities

Synthesis of oligonucleotides, deprotection, purification, desalting and lyophilization of oligonucleotides
Operate Expedite/ABI/Mermade synthesizers and HPLC systems
Prepare oligonucleotide synthesis reagents and synthesize, process, and purify ASO/siRNA using automated instruments by anion-exchange and reverse-phase HPLC systems
Desalt, concentrate, and lyophilize final Oligo’s material using appropriate instrumentation or techniques
Maintain a well-documented laboratory notebook and follow the safe laboratory practices
Operate and troubleshooting available instruments including HPLC and MS
Maintain an electronic laboratory notebook and miscellaneous documentation and maintain reagent inventory