Sr. Research Associate, Oligonucleotide Chemistry

EMD Serono Research & Development Institute•Billerica, MA

6d•Onsite

About The Position

This role is for a Sr. Research Associate in Oligonucleotide Chemistry at EMD Serono, a part of the Healthcare business. The company focuses on developing medicines, intelligent devices, and innovative technologies in therapeutic areas like Oncology, Neurology, and Fertility. They aim to help create, improve, and prolong lives. The Healthcare team offers a diverse, inclusive, and flexible working culture with opportunities for personal development and career advancement. This specific role requires external applicants to be eligible to work in the US as sponsorship is not offered.

Requirements

Bachelor’s Degree in Chemical Engineering, Chemistry, Biochemistry or related Engineering or Life Science discipline and 2+ years of Oligonucleotide chemistry experience.
OR Master’s Degree in Chemical Engineering, Chemistry, Biochemistry or related Engineering or Life Science discipline.

Nice To Haves

Good understanding of Oligonucleotide chemistry.
Experience with a wide range of Oligo purification/analytical techniques, especially HPLC and/or HPLC-MS.
Experience in performing desalting by using gel filtration or membrane filtration techniques.
High degrees of flexibility and motivation in a fast-paced work environment.

Responsibilities

Synthesis of oligonucleotides, deprotection, purification, desalting and lyophilization of oligonucleotides.
Ability to operate Expedite/ABI/Mermade synthesizers and HPLC systems.
Prepare oligonucleotide synthesis reagents and synthesize, process, and purify ASO/siRNA using automated instruments by anion-exchange and reverse-phase HPLC systems.
Desalt, concentrate, and lyophilize final Oligo’s material using appropriate instrumentation or techniques.
Maintain a well-documented laboratory notebook and follow the safe laboratory practices.
Operate and troubleshoot available instruments including HPLC and MS.
Maintain an electronic laboratory notebook and miscellaneous documentation and maintain reagent inventory.