Scientist, Oligonucleotide Sciences Analytical Chemistry

GSK•Cambridge, MA

1d•Onsite

About The Position

This role is a collaborative analytical chemistry position within GSK's pre-clinical oligonucleotide pipeline. The Scientist, Oligonucleotide Discovery Analytical Chemistry will be responsible for the analysis and quality control of GSK’s preclinical oligonucleotide therapeutics pipeline. This includes executing and developing advanced analytical methods for diverse synthetic oligonucleotide modalities to accelerate GSK’s pipeline and platform technology ambitions.

Requirements

A BS degree with at least 5 years of relevant experience or an MS degree with at least 4 years of relevant experience in analytical chemistry or a related discipline (or equivalent).
At least one year of experience using LC/MS(-MS) methodology in a biotechnology, pharmaceutical, or academic setting.
At least one year of experience performing mass spectrometry data analysis.
Demonstrable exposure to LC/MS(-MS) method development and method troubleshooting.

Nice To Haves

Professional experience in the field of oligonucleotide therapeutics.
Experience with high-resolution LC/MS(-MS) data acquisition and analysis.
Experience with high-throughput LC/MS(-MS) methodology.
Experience using reverse phase/ion-pairing, anion exchange, size-exclusion, and/or hydrophilic interaction chromatography.
Experience with other analytical methodology, such as NMR, X-ray crystallography, UV/Vis spectrophotometry, or circular dichroism.
Exposure to other aspects of drug discovery & development, including in vitro biology, bioanalysis, DMPK, delivery, etc.
Excellent communication, presentation, and documentation skills.
Familiarity working in cross-functional matrix project teams.

Responsibilities

Operate and execute validated analytical methods to enable the high-throughput oligonucleotide production platform.
Develop and deploy robust analytical methods to support in-house oligonucleotide synthesis, including novel chemistries and conjugates.
Use advanced analytical technologies to fully characterize novel synthetic oligonucleotides and related species in low- and high-throughput settings.
Collaborate internally and externally, representing Oligonucleotide Discovery Analytical Chemistry on project teams.
Support analytical investigations, including root cause analysis, in collaboration with cross-functional teams.